(Z)-2-Vinyl-but-2-enoic acid amide | 16933-67-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-2-Vinyl-but-2-enoic acid amide
• 英文别名: 2-Ethenylbut-2-enamide
• CAS: 16933-67-8
• 化学式: C₆H₉NO
• mdl: MFCD19211604
• 分子量: 111.144
• InChiKey: ACYNMOJNJDQSSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (Z)-2-Vinyl-but-2-enoic acid amide 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 为溶剂， 生成 2-乙基丁酰胺
  参考文献：
  名称：

  The reaction of chlorosulfonyl isocyanates with allenes and olefins

  摘要：

  DOI：

  10.1021/jo01272a005

文献信息

• Hydrogels for orthopedic repair
  申请人：Coury J. Arthur

  公开号：US20060093648A1

  公开（公告）日：2006-05-04

  Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high (“good” to “excellent”) adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.

  用于整形外科的水凝胶，包括软骨、骨、关节表面和相关组织的修复和再生，必须比用于软组织修复的水凝胶具有更高的强度和韧性。所提供的水凝胶配方具有高强度、韧性、适当的机械模量和低平衡水合作用。它还可以控制孔隙率或降解时间。它可以在原位聚合，对目标组织或表面具有高（"良好 "至 "卓越"）的附着力。用于形成此类凝胶的优选配方包括 40% 至 80% （按重量计）的低分子量极性单体和 30% 至 10% 的亲水性大分子交联剂。
• HYDROGELS FOR ORTHOPEDIC REPAIR
  申请人：FOCAL, INC.

  公开号：EP1231950A1

  公开（公告）日：2002-08-21
• US4255548A
  申请人：——

  公开号：US4255548A

  公开（公告）日：1981-03-10
• US7008635B1
  申请人：——

  公开号：US7008635B1

  公开（公告）日：2006-03-07
• [EN] HYDROGELS FOR ORTHOPEDIC REPAIR<br/>[FR] HYDROGELS POUR REPARATION ORTHOPEDIQUE
  申请人：FOCAL INC

  公开号：WO2001017574A1

  公开（公告）日：2001-03-15

  Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high ('good' to 'excellent') adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80 % by weight of a low-molecular weight polar monomer and 30 to 10 % of a hydrophilic macromeric crosslinker.