3-Hydroxy-pentanoyl-DL-homoserine lactone | 148433-24-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Hydroxy-pentanoyl-DL-homoserine lactone
• 英文别名: 3-hydroxy-N-(2-oxooxolan-3-yl)pentanamide
• CAS: 148433-24-3
• 化学式: C₉H₁₅NO₄
• 分子量: 201.222
• InChiKey: IZXCXPQWOXJOPE-UHFFFAOYSA-N

物化性质

• 沸点：
  499.5±45.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Methods for the treatment of an infectious bacterial disease with anti-lactone or lactone derived signal molecules antibody
  申请人：Haptogen Ltd

  公开号：EP2260868A2

  公开（公告）日：2010-12-15

  The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins and used to isolate high affinity receptors recognising the native signal molecule(s). By binding to signalling molecules, the receptors reduce and maintain extra-cellular concentrations of signal molecules below the threshold level that would otherwise result in certain opportunistic pathogens adopting a virulent form, and can transform virulent organisms to non-virulent states. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease monitoring and management, and in related applications where the host for infection is an animal or plant.

  本发明涉及通过调节细菌细胞信号分子的细胞外浓度来控制传染性细菌毒力的方法。细胞信号分子的衍生物与适当的载体蛋白连接，并用于分离识别原生信号分子的高亲和力受体。通过与信号分子结合，受体可将信号分子的细胞外浓度降低并维持在阈值水平以下，否则会导致某些机会性病原体采取毒性形式，并可将毒性生物转化为非毒性状态。这些受体可用于治疗易受感染者、治疗现有感染患者、疾病监测和管理，以及感染宿主为动物或植物的相关应用。
• Methods for inducing autolysis in infectious bacteria
  申请人：Haptogen Ltd

  公开号：EP2261260A2

  公开（公告）日：2010-12-15

  The present invention relates to methods for the killing of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. This has the effect of inducing rapid cell death (autolysis) in the majority of bacterial cells, and preventing virulence or restoring a benign state in surviving cells. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease management, and in related applications where the host for infection is an animal or plant. The compositions described herein are particularly relevant to Pseudomonas aeruginosa infection, for example in the treatment of pulmonary infection in cystic fibrosis patients, and represent a unique bactericidal medication that does not directly target the bacteria.

  本发明涉及通过调节细菌细胞信号分子的细胞外浓度来杀死传染性细菌的方法。其效果是诱导大多数细菌细胞快速死亡（自溶），防止毒力增强或使存活细胞恢复良性状态。这些受体可用于治疗易受感染的个体、治疗已有感染的病人、疾病管理以及感染宿主为动物或植物的相关应用。本文所述组合物尤其适用于铜绿假单胞菌感染，例如用于治疗囊性纤维化患者的肺部感染，是一种不直接针对细菌的独特杀菌药物。
• Methods for reducing biofilm formation in infectious bacteria
  申请人：Haptogen Ltd

  公开号：EP2281839A2

  公开（公告）日：2011-02-09

  The present invention provides methods of preventing or inhibiting biofilm formation by a population of bacteria, said method comprising the administration to the population of an antibody to a lactone or lactone-derived signal molecule secreted by bacteria. The invention therefore also provides methods for the treatment of bacterial infection in biofilm formation is prevented or inhibited.

  本发明提供了防止或抑制细菌群体形成生物膜的方法，所述方法包括向细菌群体施用针对细菌分泌的内酯或内酯衍生信号分子的抗体。因此，本发明还提供了在防止或抑制生物膜形成的情况下治疗细菌感染的方法。
• METHODS FOR THE TREATMENT OF AN INFECTIOUS BACTERIAL DISEASE WITH AN ANTI-LACTONE OR LACTONE DERIVED SIGNAL MOLECULES ANTIBODY
  申请人：Haptogen Ltd

  公开号：EP1528935B1

  公开（公告）日：2012-03-21
• METHODS FOR INDUCING AUTOLYSIS IN INFECTIOUS BACTERIA
  申请人：Haptogen Ltd

  公开号：EP1730197B1

  公开（公告）日：2012-03-07