dichloro-ethenyl-[(4-methoxyphenyl)methyl]silane | 156387-05-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: dichloro-ethenyl-[(4-methoxyphenyl)methyl]silane
• CAS: 156387-05-2
• 化学式: C₁₀H₁₂Cl₂OSi
• 分子量: 247.196
• InChiKey: AGNZAEMWONQOAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  14.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  甲醇 、 dichloro-ethenyl-[(4-methoxyphenyl)methyl]silane 在 三氯化铝 、 三乙胺 、 sodium chloride 作用下， 生成 2,2,6-trimethoxy-3,4-dihydro-1H-2-benzosiline
  参考文献：
  名称：

  Synthesis of 2-Silatetralin Derivatives Bearing Oxygen Functional Groups

  摘要：

  The Grignard reagents of methoxy- or methylene-dioxyphenylmethyl chlorides (12a-e) were treated with trichloro-vinylsilane in THF or ether to give methoxy- or methylenedioxy-benzyldichlorovinylsilanes (13a-e). The reaction of 13a-d in the presence of AlCl3 in CS2 or CH2Cl2 followed by treatment with MeOH and cyclohexylamine or Et3N afforded methoxy-2-silatetralins (16a-d). Treatment of 16a-d with MeMgl or EtMgBr in ether gave the corresponding 2,2-dimethyl- or 2,2-diethyl-2-silatetralins (17a-d or 18). Demethylation of 17a, 17b or 18 with BBr3 in CH2Cl2 furnished hydroxy-2-silatetralins (19a, 19b or 20).

  DOI：

  10.3987/com-93-6659
• 作为产物：
  描述：

  trichlorovinylsilane 、 4-甲氧基氯苄 在 碘 、 magnesium 作用下， 生成 dichloro-ethenyl-[(4-methoxyphenyl)methyl]silane
  参考文献：
  名称：

  Synthesis of 2-Silatetralin Derivatives Bearing Oxygen Functional Groups

  摘要：

  The Grignard reagents of methoxy- or methylene-dioxyphenylmethyl chlorides (12a-e) were treated with trichloro-vinylsilane in THF or ether to give methoxy- or methylenedioxy-benzyldichlorovinylsilanes (13a-e). The reaction of 13a-d in the presence of AlCl3 in CS2 or CH2Cl2 followed by treatment with MeOH and cyclohexylamine or Et3N afforded methoxy-2-silatetralins (16a-d). Treatment of 16a-d with MeMgl or EtMgBr in ether gave the corresponding 2,2-dimethyl- or 2,2-diethyl-2-silatetralins (17a-d or 18). Demethylation of 17a, 17b or 18 with BBr3 in CH2Cl2 furnished hydroxy-2-silatetralins (19a, 19b or 20).

  DOI：

  10.3987/com-93-6659