[(1S,2S,3S,4R)-4-(2,6-diaminopurin-9-yl)-2,3-dihydroxycyclopentyl] sulfamate | 1031730-66-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: [(1S,2S,3S,4R)-4-(2,6-diaminopurin-9-yl)-2,3-dihydroxycyclopentyl] sulfamate
• CAS: 1031730-66-1
• 化学式: C₁₀H₁₅N₇O₅S
• 分子量: 345.339
• InChiKey: OKPSBDFQGCZICS-LPWJYYESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  214
• 氢给体数：
  5
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  在 氨 作用下， 以 甲醇 为溶剂， 反应 18.0h， 生成 [(1S,2S,3S,4R)-4-(2,6-diaminopurin-9-yl)-2,3-dihydroxycyclopentyl] sulfamate
  参考文献：
  名称：

  Synthesis of 4′-modified noraristeromycins to clarify the effect of the 4′-hydroxyl groups for inhibitory activity against S-adenosyl-l-homocysteine hydrolase

  摘要：

  4'-Modified noraristeromycin (NAM) analogs, 4'-sulfo-, 4'-sulfamoy, 4'-azido and 4'-amino-NAM, were systematically synthesized. The inhibitory activities of these analogs and related compounds against Plasmodium falciparum and human S-adenosyl-L-homocysteine hydrolase were investigated. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.03.029