[({2-[3-(acetyloxy)phenyl]-4-methyl-1,3-oxazol-5-yl}carbonyl)(pyridin-2-ylmethyl)amino]acetic acid | 1016644-81-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [({2-[3-(acetyloxy)phenyl]-4-methyl-1,3-oxazol-5-yl}carbonyl)(pyridin-2-ylmethyl)amino]acetic acid
• 英文别名: 2-[[2-(3-Acetyloxyphenyl)-4-methyl-1,3-oxazole-5-carbonyl]-(pyridin-2-ylmethyl)amino]acetic acid
• CAS: 1016644-81-7
• 化学式: C₂₁H₁₉N₃O₆
• 分子量: 409.398
• InChiKey: YPBROKHJDLOVJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  benzyl ({2-[3-(acetyloxy)phenyl]-4-methyl-1,3-oxazol-5-yl}carbonyl)(pyridin-2-ylmethyl)aminoacetate 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、600.01 kPa 条件下， 反应 48.0h， 以21%的产率得到[({2-[3-(acetyloxy)phenyl]-4-methyl-1,3-oxazol-5-yl}carbonyl)(pyridin-2-ylmethyl)amino]acetic acid
  参考文献：
  名称：

  Chemical inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors

  摘要：

  本发明涉及具有抑制庚糖合成特性的新化合物，其具有式(I)或其药学上可接受的盐或前药，其中A为芳基或杂环，任选地被一个或多个相同或不同的R取代，如H、C1-C10烷基、C1-C10烷基-OR1、C1-C10烷基-NR1R1、烷氧基、羟基、硫代烷基、芳基、杂环、卤素、硝基、氰基、CO2R1、NR1R1、NR1C(O)R1、C(O)NR1R1、NR1C(S)R1、C(S)NR1R1、SO2NR1R1、SO2R1、NR1SO2R1、NR1C(O)NR1R1、NR1C(O)OR1、NR1C(S)NR1R1、NR1C(S)OR1、R1C═NOR1、C(O)R1、芳氧基、硫代芳基、烯基、炔基，R1相同或不同为H或C1-C10烷基；B1、B2、B3相同或不同，代表C、N、O、S以形成五元芳香环，其中一到三个碳原子被选自S、O、N的杂原子替换，任选地被一个或多个相同或不同的如上定义的R取代；B4为C或N；Y为H、C1-C10烷基、烷氧基、硫代烷基，任选地被一个或多个相同或不同的如上定义的R取代；W为C、O或N，被或不被一个或多个C1-C10烷基基团取代；D为任选地被一个或多个相同或不同的如上定义的R取代的杂环。

  公开号：

  US20100022541A1

文献信息

• PHOSPHORUS ACID FUNCTIONALIZED COATING COMPOSITION
  申请人：ROHM AND HAAS COMPANY

  公开号：EP3106526A1

  公开（公告）日：2016-12-21

  The present invention relates to a composition comprising an aqueous dispersion of submicron-sized polymer particles and micron-sized polymer beads, wherein the polymer particles or beads or both are functionalized with phosphorus acid groups. The composition of the present invention is useful for providing a matte finish on substrates, such as leather, textiles, wallboard, decorative coatings, concrete, and wood, with improved stain resistance. The present invention also relates to a leather substrate coated with a clear matte finish comprising an acrylic or styrene-acrylic polymer film and micron-sized polymer beads, wherein the film or the beads or both are functionalized with a phosphorus acid monomer.

  本发明涉及一种组合物，该组合物包含亚微米级聚合物颗粒和微米级聚合物珠子的水性分散体，其中聚合物颗粒或珠子或两者都被磷酸基团官能化。本发明的组合物可用于在皮革、纺织品、墙板、装饰涂料、混凝土和木材等基材上提供亚光效果，并提高抗污性。本发明还涉及一种涂有透明亚光涂层的皮革基材，该基材由丙烯酸或苯乙烯-丙烯酸聚合物薄膜和微米大小的聚合物珠子组成，其中薄膜或珠子或两者都被磷酸单体官能化。
• Phosphorus acid functionalized coating composition
  申请人：Rohm and Haas Company

  公开号：US11254990B2

  公开（公告）日：2022-02-22

  The present invention relates to a composition comprising an aqueous dispersion of submicron-sized polymer particles and micron-sized polymer beads, wherein the polymer particles or beads or both are functionalized with phosphorus acid groups. The composition of the present invention is useful for providing a matte finish on substrates, such as leather, textiles, wallboard, decorative coatings, concrete, and wood, with improved stain resistance. The present invention also relates to a leather substrate coated with a clear matte finish comprising an acrylic or styrene-acrylic polymer film and micron-sized polymer beads, wherein the film or the beads or both are functionalized with a phosphorus acid monomer.

  本发明涉及一种组合物，该组合物包含亚微米级聚合物颗粒和微米级聚合物珠子的水性分散体，其中聚合物颗粒或珠子或两者都被磷酸基团官能化。本发明的组合物可用于在皮革、纺织品、墙板、装饰涂料、混凝土和木材等基材上提供亚光效果，并提高抗污性。本发明还涉及一种涂有透明亚光涂层的皮革基材，该基材由丙烯酸或苯乙烯-丙烯酸聚合物薄膜和微米大小的聚合物珠子组成，其中薄膜或珠子或两者都被磷酸单体官能化。
• SUBSTITUTED HETEROCYCLYLCARBONYLAMINO-ACETIC-ACID-DERIVATIVES AS INHIBITORS OF BACTERIAL HEPTOSE SYNTHESIS, METHODS FOR THEIR PREPARATION AND BIOLOGICAL APPLICATIONS OF SAID INHIBITORS
  申请人：Mutabilis SA

  公开号：EP2104671A2

  公开（公告）日：2009-09-30
• A METAL OXIDE DISPERSION AND USES THEREOF
  申请人：Novartis AG

  公开号：EP3074213B1

  公开（公告）日：2018-09-26
• INHIBITION OF POLYMERISATION
  申请人：Loyns Richard Colin

  公开号：US20100168434A1

  公开（公告）日：2010-07-01

  The present invention provides methods and compositions for inhibiting polymerisation of ethylenically unsaturated monomers, which involve the use of nitroxide compound of formula (I): wherein R 1 is C 4-20 hydrocarbyl; and R 2 , R 3 , R 4 and R 5 are independently each C 1-6 alkyl.