Lithium,[1-[(1R,2R,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]-1H-inden-1-yl]- | 148200-42-4

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: Lithium,[1-[(1R,2R,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]-1H-inden-1-yl]-
• 英文别名: (1-neoisomenthylindenyl)lithium
• CAS: 148200-42-4
• 化学式: C₁₉H₂₅Li
• 分子量: 260.348
• InChiKey: YKLMDSKWCBSJCE-XKRFURIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.0
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  氯化锆(IV) 、 Lithium,[1-[(1R,2R,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]-1H-inden-1-yl]- 以 甲苯 为溶剂， 以21%的产率得到(+)-bis(1-neoisomenthylindenyl)zirconium dichloride
  参考文献：
  名称：

  Conformational Analysis of Nonbridged Bent Metallocene Ziegler-Catalyst PrecursorsDetection of the Third Torsional Isomer

  摘要：

  The series of (1-terpenylindenyl)(2)ZrCl2 bent metallocene complexes (with terpenyl substituents neomenthyl, neoisomenthyl, menthyl, and isomenthyl) were obtained from the reaction of the respective 1-terpenylindenyl lithium reagents with ZrCl4. In each case a single racem-like diastereoisomer was isolated pure by crystallization. The conformational analysis of the bent metallocene systems was carried out by variable temperature H-1 NMR spectroscopy. It has revealed the existence and equilibration of three different bent metallocene torsional isomers. Two of these are C-2-symmetric and carry their bulky terpenyl substituents either in the lateral or the front sector of the bent metallocene wedge (descriptors bis-lateral:anti (conformer A) and bis-central:syn (conformer B)), whereas the rotational isomer C (central, lateral:gauche) is of lower symmetry. The (1-terpenylindenyl)(2)ZrCl2/methylalumoxane systems are active propene polymerization catalysts. The equilibrium amount of the ''stereochemically productive'' C-2-symmetric bis-lateral:anti bent metallocene conformer A correlates qualitatively with the observed isotacticity of the propene polymerization process at the respective group 4 bent metallocene catalyst system.

  DOI：

  10.1021/ja9608048
• 作为产物：
  描述：

  indenyllithium 在 甲基锂 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 74.0h， 生成 Lithium,[1-[(1R,2R,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]-1H-inden-1-yl]-
  参考文献：
  名称：

  The role of torsional isomers of planarly chiral nonbridged bis(indenyl)metal type complexes in stereoselective propene polymerization

  摘要：

  Reaction of enantiomerically pure (1-neomenthylindenyl)lithium with ZrCl4(THF)2 gave the three diastereomeric bis(1-neomenthylindenyl)zirconium dichloride complexes 4a-A,-B,and -C, in a 93:2:5 ratio. Similarly, a 82:7:11 mixture of the three bis(1-neoisomenthylindenyl)zirconium dichloride diastereoisomers (4b-A,B,C) was obtained from (1-neoisomenthylindenyl)lithium and the zirconium tetrachloride-bis(tetrahydrofuran) adduct. Recrystallization from methylene chloride furnished the (optically active) pure diastereomers 4a-A and 4b-A, respectively. Catalytic hydrogenation (PtO2, 50-60 bar of H-2, CH2Cl2) converted them into the pure (p-S, p-S)-bis(1-neomenthyl-4,5,6,7-tetrahydroindenyl)zirconium dichloride (5a-A) and (p-R,p-R)-bis(1-neoisomenthyl-4,5,6,7-tetrahydroindenyl)zirconium dichloride (5b-A) complexes. All four metallocenes were characterized by X-ray crystal structure analyses. Complex 4a-A crystallizes in space group P2 with cell parameters a = 10.510(1) angstrom, b = 6.975(1) angstrom, c = 12.421(1) angstrom, beta = 108.18(1)degrees, Z = 1, R = 0.037, R(w) = 0.041; 4b-A P2(1), a = 7.559(2) angstrom, b = 9.046(2) angstrom, c = 25.015(3) angstrom, beta = 96.72(1)degrees, Z = 2, R = 0.037, R(w) = 0.040; 5a-A P2(1)2(1)2, a = 15.422(1) angstrom, b = 18.716(1) angstrom, c = 7.118(1) angstrom, Z = 2, R = 0.062, R(w) = 0.074; 5b-A P2(1)2(1)2, a = 10.103(1) angstrom, b = 26.626(5) angstrom, c = 6.762(1) angstrom, Z = 2, R = 0.030, R(w) = 0.037. Complexes 4a-A, 5a-A, and 5b-A exhibit C2-symmetric bent metallocene conformations in the crystal which are characterized as having the bulky terpenyl substituents oriented antiperiplanarly toward the lateral sectors of the bent metallocene wedge (''bis-lateral:anti'' conformation). In contrast, the bis(neoisomenthylindenyl)zirconium dichloride complex 4b-A has only one hydrocarbyl substituent arranged laterally whereas the other is oriented to the open front side of the metallocene backbone (C1-symmetric ''central,lateral:gauche'' conformation). In solution the conformational behavior of these complexes is different. By dynamic temperature-dependent H-1 and C-13 NMR spectroscopy both neoisomenthyl-substituted complexes 4b-A and 5b-A appear as single C2-symmetric species in solution. In contrast, the neomenthyl-substituted complexes 4a-A and 5a-A exhibit equilibrating conformational mixtures. In the case of the (p-S,p-S)-bis(1-neomenthyl-4,5,6,7-tetrahydroindenyl)zirconium dichloride system (5a-A) it was shown that two conformational isomers are present in a ca. 80:20 ratio. These are C2- (major isomer) and C1-symmetric (minor isomer) and probably correspond to the ''bis-lateral:anti'' and ''central,lateral:gauche'' conformational types, respectively, that were identified by X-ray diffraction in the crystal. These conformational properties seem to determine the outcome of the stereoselective propene polymerization to a considerable extent, which was carried out at homogeneous bent metallocene/methylalumoxane Ziegler-type catalysts derived from the complexes 4 and 5. Both neoisomenthyl-substituted systems produce isotactic high molecular weight polypropylene with purely enantiomorphic site control at low temperature. The isomeric neomenthyl-substituted systems are much less stereoselective.It is assumed that the bis(1-neomenthyltetrahydroindenyl)zirconium catalyst switches back and forth between the C2- and C1-symmetric conformations of the bent metallocene backbone during the catalytic process, thereby probably giving rise to the formation of alternating isotactic and near to atactic sequences along the growing polymer chain.

  DOI：

  10.1021/ja00064a022