divinyl maleate | 3234-32-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: divinyl maleate
• 英文别名: maleic acid divinyl ester；Maleinsaeure-divinylester；vinyl maleate；Divinyl-maleat；Maleinsauredivinylester；bis(ethenyl) (Z)-but-2-enedioate
• CAS: 3234-32-0
• 化学式: C₈H₈O₄
• 分子量: 168.149
• InChiKey: ORZGJQJXBLFGRP-WAYWQWQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  divinyl maleate 、 去氧肾上腺素碱 在 N,N-二异丙基乙胺 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以3.21 g的产率得到
  参考文献：
  名称：

  一种苯肾上腺素杂质及其制备方法和应用

  摘要：

  本发明公开了一种苯肾上腺素杂质及其制备方法和应用，涉及化学合成技术领域。本发明提供的苯肾上腺素杂质的制备方法，以苯肾上腺素为起始原料，在碱性条件下与马来酸酯缩合，再经水解即可快速得到目标产物，即(R)‑2‑[N‑甲基‑N‑[[2‑羟基‑2‑(3‑羟基)苯基]乙基]氨基‑丁二酸。本发明方法操作简单，成本低廉，具有很高的商业价值；通过本发明制备方法所得到的苯肾上腺素杂质为苯肾上腺素的质量控制提供了合格、廉价、高质量的杂质对照品，解决了该杂质合成过程中路线长、收率低、操作危险等技术问题，对苯肾上腺素用药安全有重要意义。

  公开号：

  CN113717068A
• 作为产物：
  描述：

  2(5H)-呋喃酮,5,5-二氯-(9CI) 、 乙醛 在 吡啶 作用下， 生成 divinyl maleate
  参考文献：
  名称：

  Sladkow; Petrow, Zhurnal Obshchei Khimii, 1954, vol. 24, p. 450,452;engl.Ausg.S.459,460

  摘要：

  DOI：

文献信息

• Oligomeric hindered amine light stabilizers based on multi-functional carbonyl compounds and methods of making same
  申请人：——

  公开号：US20020087000A1

  公开（公告）日：2002-07-04

  Oligomeric compounds and methods of making the compound having the formula: T&Parenopenst;E-F&Parenclosest; i &Parenopenst;E-F′&Parenclosest; j &Parenopenst;E′-F&Parenclosest; k &Parenopenst;E′-F′&Parenclosest; l S  (II) wherein i, j, k, and l are integers from about 0 to 300 and the sum of i, j, k, and l is greater than 2, wherein the units F, F′ and T are derived from one or more multi-functional carbonyl compounds of general structure DO—CO—CR a R b —(—CR c R d —) n —NH—(Y) m —CO—OD  (IV) wherein n is an integer from 1 to 15, m is either 0 or 1; R a , R b , R c , and R d , are each a hydrogen or a hydrocarbyl group; Y is CO—(CR e R f ) p , wherein R e and R f are each a hydrogen or hydrocarbyl group and p is zero or an integer from 1 to 20 or CO—C 6 H 4 —, wherein the substitution pattern on the phenylene group is an ortho, meta, or para substitution pattern, and one or more of the hydrogens of the phenylene group may be substituted by a hydrocarbyl group or a functional group; and D is a hydrocarbyl group and the units E, E′ and S are derived from one or more 1-substituted piperidin-4-ol or 4-aminopiperidines of general structure 1 wherein Z is OH or NHG, wherein G is H or C 1 -C 12 alkyl, R 1 is —(CH 2 ) s —OH, —(CH 2 ) s —NH 2 , C 1 -C 18 hydroxyalkoxy or C 5 -C 12 hydroxycycloalkoxy; wherein s is an integer from 1 to 10; R 2 represents hydrogen, C 1 -C 8 alkyl, or benzyl; R 3 , R 4 , R 5 , and R 6 are each a hydrogen, C 1 -C 8 alkyl, benzyl or phenethyl, or two geminal R moieties, which together with the carbon to which they are attached form a C 5 -C 10 cycloalkyl. The compounds are useful for stabilizing polymer compositions against photo- and thermal degradation.

  含有以下公式的化合物的寡聚体化合物及其制备方法：T&Parenopenst;E-F&Parenclosest;i&Parenopenst;E-F′&Parenclosest;j&Parenopenst;E′-F&Parenclosest;k&Parenopenst;E′-F′&Parenclosest;lS  (II)，其中i、j、k和l为约0至300的整数，且i、j、k和l的总和大于2，其中单位F、F′和T来源于一个或多个具有一般结构DO—CO—CRaRb—(—CRcRd—)n—NH—(Y)m—CO—OD  (IV)的多功能羰基化合物，其中n为1至15的整数，m为0或1；Ra、Rb、Rc和Rd分别为氢或烃基团；Y为CO—(CReRf)p，其中Re和Rf分别为氢或烃基团，p为0或1至20的整数，或CO—C6H4—，苯环基上的取代模式为邻位、间位或对位取代模式，苯环基的一个或多个氢原子可被烃基团或功能基团取代；D为烃基团，单位E、E′和S来源于一个或多个具有一般结构1的1-取代哌啶-4-醇或4-氨基哌啶，其中Z为OH或NHG，G为H或C1-C12烷基，R1为—(CH2)s—OH、—(CH2)s—NH2、C1-C18羟基烷氧基或C5-C12羟基环烷氧基，其中s为1至10的整数；R2代表氢、C1-C8烷基或苄基；R3、R4、R5和R6分别为氢、C1-C8烷基、苄基或苯乙基，或两个伪生R基团，它们与它们附着的碳形成C5-C10环烷基。这些化合物可用于稳定聚合物组合物对光和热降解的作用。
• Hindered amine light stabilizers based on multi-functional carbonyl compounds and methods of making same
  申请人：——

  公开号：US20020099218A1

  公开（公告）日：2002-07-25

  Compounds and methods of preparing compounds of the formula: RZ—CO—CR a R b —(CR c R d ) n —NH—(Y) m —CO—A  (I) wherein n is an integer from 1 to 15, m is either 0 or 1; R a , R b , R c , and R d are each a hydrogen or a hydrocarbyl group; Y is CO—(CR e R f ) p , wherein R e and R f are each a hydrogen or hydrocarbyl group and p is zero or an integer from 1 to 20 or CO—C 6 H 4 —, wherein the substitution pattern on the phenylene group is an ortho, meta, or para substitution pattern and one or more of the hydrogens of the phenylene group may be substituted by a hydrocarbyl group or a functional group; Z is —O— or —NG—, wherein G is H, C 1 -C 12 alkyl or the radical R; wherein R is 1 wherein R 1 is hydrogen, C 1 -C 18 alkyl, O, OH, CH 2 CN, C 1 -C 18 alkoxy, C-C 18 hydroxyalkoxy, C 5 -C 12 cycloalkoxy, C 5 -C 12 hydroxycycloalkoxy, C 3 -C 6 alkenyl, C 1 -C 18 alkynyl, C 7 -C 9 phenylalkyl, unsubstituted or substituted on the phenyl with 1, 2 or 3 C 1 -C 4 alkyls, or an aliphatic C 1 -C 8 acyl; R 2 is hydrogen, C 1 -C 8 alkyl, or benzyl; R 3 , R 4 , R 5 , and R 6 are each a hydrogen, C 1 -C 8 alkyl, benzyl or phenethyl, or two geminal R moieties, which together with the carbon to which they are attached form a C 5 -C 10 cycloalkyl; and A is either ZR or a hydrocarbyl group, which are useful for stabilizing polymer compositions against photo- and thermal degradation.

  该公式的化合物及其制备方法：RZ—CO—CRaRb—(CRcRd)n—NH—(Y)m—CO—A（I）其中n是1到15之间的整数，m为0或1；Ra、Rb、Rc和Rd分别是氢或烃基团；Y是CO—(CReRf)p，其中Re和Rf分别是氢或烃基团，p为0或1到20之间的整数，或CO—C6H4—，其中苯环上的取代模式为邻位、间位或对位取代模式，苯环的一个或多个氢原子可能被烃基团或功能基团取代；Z是—O—或—NG—，其中G是H、C1-C12烷基或基团R；其中R是1其中R1是氢、C1-C18烷基、O、OH、CH2CN、C1-C18甲氧基、C-C18羟基甲氧基、C5-C12环氧基、C5-C12羟基环氧基、C3-C6烯基、C1-C18炔基、C7-C9苯基烷基，苯基上未取代或取代1、2或3个C1-C4烷基，或脂肪族C1-C8酰基；R2是氢、C1-C8烷基或苄基；R3、R4、R5和R6分别是氢、C1-C8烷基、苄基或苯乙基，或两个共轭的R基，与它们附着的碳形成C5-C10环烷基；A是ZR或烃基团，可用于稳定聚合物组合物对光和热降解的影响。
• N-[2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl]oxamides as light stabilisers
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0593936A1

  公开（公告）日：1994-04-27

  This invention relates to novel UV absorbers, their methods of preparation, their use in stabilizing polymers and polymers so stabilized against the degradative effects of UV light. The novel compounds of formula I are oxamides which are substituted on one or both nitrogens with a 2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl group. The 2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl groups are efficient UV absorbing groups and the oxamide group contributes additional light stabilizing, heat stabilizing and metal complexing properties to the compounds. The compounds have low-volatility and are especially useful as UV stabilizers for engineering resins processed at high temperatures.

  这项发明涉及新型紫外线吸收剂，其制备方法，其在稳定聚合物中的使用以及通过紫外线光的降解作用而得到稳定的聚合物。公式I的新型化合物是氧酰胺，其在一个或两个氮上被2-羟基-3-(2H-苯并三唑-2-基)苯甲基基团取代。2-羟基-3-(2H-苯并三唑-2-基)苯甲基基团是高效的紫外线吸收基团，而氧酰胺基团则为化合物提供了额外的光稳定、热稳定和金属络合性能。这些化合物具有低挥发性，特别适用于在高温下加工的工程树脂的紫外线稳定剂。
• Carbamates of rapamycin
  申请人：Wyeth

  公开号：EP1266900A1

  公开（公告）日：2002-12-18

  The invention concerns a compound of the structure wherein R1 and R2 are each, independently, hydrogen, -CONH-[(CR3R4)m(-A-(CR5R6)n)p]q-B; R3, R4, R5, R6, R9 and R10 are each defined substitutents, and R3-6 may each also represent hydrogen, B is alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, hydroxyalkyl of 1-6 carbon atoms, alkylthioalkyl of 2-12 carbon atoms, alkylaminoalkyl of 2-12 carbon atoms, dialkylaminoalkyl of 3-12 carbon atoms, -OR7, -SR7, -CN, -COR7, -CONHR7, -OSO3R7, -NR7R8, -NHCOR7, -NHSO2R7, or Ar; A is -CH2-, -NR7-, -O-, -S-, -SO-, -PR7-, -NHCO-, -NHSO- or -P(O)(R7)-; Ar is naphthyl, pyridyl, quinolyl, isoquinolyl, quinoxalyl, thienyl, thionaphthyl, furyl, benzofuryl, benzodioxyl, benzoxazolyl, benzoisoxazolyl, indolyl, thiazolyl, isoxazolyl, pyrimidinyl, pyrazinyl, imidazolyl, benzopyranyl, benz[b]thiophenolyl, benzimidazolyl, benzthiazolyl, benzodioxolyl, piperidinyl, morpholinyl, piperazinyl, tetrahydrofuranyl, or pyrrolidinyl; wherein the Ar group may be optionally mono-, di-, or tri- substituted with a group selected from alkyl of 1-6 carbon atoms, arylalkyl of 7-10 carbon atoms, alkoxy of 1-6 carbon atoms, cyano, halo, hydroxy, nitro, carbalkoxy of 2-7 carbon atoms, trifluoromethyl, amino, dialkylamino of 1-6 carbon atoms per alkyl group, dialkylaminoalkyl of 3-12 carbon atoms, hydroxyalkyl of 1-6 carbon atoms, alkoxyalkyl of 2-12 carbon atoms, alkylthio of 1-6 carbon atoms, -SO3H -PO3H, and -CO2H; PO3H, and -CO2H; is a nitrogen containing heterocycle that may be saturated, unsaturated, or partially unsaturated, and may be optionally mono-, di-, or tri- substituted with a defined substituent, with the proviso that R1 and R2 are not both hydrogen; m=0-6; n=0-6; p=0-1; q=0-1; or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.

  该发明涉及一种具有以下结构的化合物，其中R1和R2分别独立地为氢，-CONH-[(CR3R4)m(-A-(CR5R6)n)p]q-B；R3、R4、R5、R6、R9和R10均为定义的取代基，R3-6也可以分别表示氢，B为2-7个碳原子的烯基，2-7个碳原子的炔基，1-6个碳原子的羟基烷基，2-12个碳原子的烷硫基烷基，2-12个碳原子的烷基氨基烷基，3-12个碳原子的二烷基氨基烷基，-OR7，-SR7，-CN，-COR7，-CONHR7，-OSO3R7，-NR7R8，-NHCOR7，-NHSO2R7或Ar；A为-CH2-，-NR7-，-O-，-S-，-SO-，-PR7-，-NHCO-，-NHSO-或-P(O)(R7)-；Ar为萘基，吡啶基，喹啉基，异喹啉基，喹啉基，噻吩基，噻萘基，呋喃基，苯并呋喃基，苯二氧基基，苯氧唑基，苯并异唑基，吲哚基，噻唑基，异噁唑基，嘧啶基，吡啉基，咪唑基，苯并吡喃基，苯并噻吩基，苯并咪唑基，苯并噻唑基，苯二氧唑基，哌啶基，吗啉基，哌嗪基，四氢呋喃基或吡咯烷基；其中Ar基可以选择性地单取代、双取代或三取代，取代基可选自1-6个碳原子的烷基，7-10个碳原子的芳基烷基，1-6个碳原子的烷氧基，氰基，卤素，羟基，硝基，2-7个碳原子的羰基烷氧基，三氟甲基，氨基，1-6个碳原子的二烷基氨基，3-12个碳原子的二烷基氨基烷基，1-6个碳原子的羟基烷基，2-12个碳原子的烷氧基烷基，1-6个碳原子的烷硫基，-SO3H，-PO3H和-CO2H；PO3H和-CO2H；是一种含氮杂环，可以饱和、不饱和或部分不饱和，并且可以选择性地单取代、双取代或三取代具有定义的取代基，但R1和R2不能同时为氢；m=0-6；n=0-6；p=0-1；q=0-1；或其药学上可接受的盐，可用作免疫抑制剂、抗炎剂、抗真菌剂、抗增殖剂和抗肿瘤剂。
• Emulsion composition of modified polypropylene
  申请人：Ozaki Hiroyuki

  公开号：US20070004847A1

  公开（公告）日：2007-01-04

  An emulsion composition of a modified polypropylene. It can have exceedingly improved emulsion stability because the modified polypropylene used has extremely high solubility in solvents and is easily emulsifiable. The modified-polypropylene emulsion composition comprises water and a modified polypropylene dispersed and emulsified therein, and is characterized in that the modified polypropylene has a racemic diad content [r] of 0.12 to 0.88 and has hydrophilic functional groups in a number of 0.5 or larger on the average per molecular chain of the polypropylene.

  一种改性聚丙烯的乳液组合物。它可以具有极大改善的乳液稳定性，因为所使用的改性聚丙烯在溶剂中具有极高的溶解度，并且易于乳化。改性聚丙烯乳液组合物包括水和分散和乳化其中的改性聚丙烯，其特征在于改性聚丙烯的嘧啶二聚物含量[r]为0.12至0.88，并且在聚丙烯的每条分子链上平均有0.5个或更多的亲水性功能基团。