2-chloro-2'-O-methyl-adenosine | 116525-87-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-chloro-2'-O-methyl-adenosine
• 英文别名: (2R,3R,4R,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
• CAS: 116525-87-2
• 化学式: C₁₁H₁₄ClN₅O₄
• 分子量: 315.716
• InChiKey: IYZJBBVSFQSIQY-KQYNXXCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Process for the production of 2-halo-6-aminopurine derivatives
  申请人：Reliable Biopharmaceutical, Inc.

  公开号：US20020052492A1

  公开（公告）日：2002-05-02

  A novel process for preparing 2-halo-6-aminopurine derivatives and their analogs is disclosed. The method comprises halogenation of 2,6-diaminopurine derivatives at the C-2 position in a specific combination of aprotic polar and nonpolar organic solvents to give the corresponding halogenated derivatives.

  公开了一种制备2-卤代-6-氨基嘌呤衍生物及其类似物的新型工艺。该方法包括在无极性极性和非极性有机溶剂的特定组合中卤代2,6-二氨基嘌呤衍生物的C-2位置，以得到相应的卤代衍生物。
• Adenosindeaminase inhibitor
  申请人：NIPPON ZOKI PHARMACEUTICAL CO., LTD.

  公开号：EP0601322A2

  公开（公告）日：1994-06-15

  The use of a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof wherein each of R₁, R₂ and R₃ which may be same or different is hydrogen or alkyl; and R and X have the meanings given in the specification, for the preparation of a medicament which is an adenosinedeaminase inhibitor is disclosed. Some of the compounds of formula (I) are novel compounds. They may be used for the making of a medicament which is for the prevention or therapy of ischemic heart diseases, diseases caused by cerebrovascular disorders, renal diseases and allergic diseases and of post-operative complicated diseases involved with activated oxygen which is generated in ischemic areas during the recirculation of blood after operations.

  使用以下通式（I）代表的化合物或其药学上可接受的盐 其中R₁、R₂和R₃可以相同或不同，各自为氢或烷基；R和X具有说明书中给出的含义。一些式（I）化合物是新型化合物。它们可用于制备预防或治疗缺血性心脏病、脑血管疾病、肾脏疾病和过敏性疾病以及术后复杂疾病的药物，这些疾病与术后血液再循环过程中在缺血区域产生的活性氧有关。
• Novel adenosine derivatives and pharmaceutical compositions containing them as an active ingredient
  申请人：NIPPON ZOKI PHARMACEUTICAL CO. LTD.

  公开号：EP0269574B1

  公开（公告）日：1992-03-18
• US4843066A
  申请人：——

  公开号：US4843066A

  公开（公告）日：1989-06-27
• US5658731A
  申请人：——

  公开号：US5658731A

  公开（公告）日：1997-08-19