(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | 907561-76-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: (1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
• 英文别名: (1R,2R,3S,4R,5S)-4-(6-amino-2-methylsulfanylpurin-9-yl)-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
• CAS: 907561-76-6
• 化学式: C₁₃H₁₇N₅O₃S
• 分子量: 323.37
• InChiKey: JIOYSICKCSNHFB-XEMBYONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  156
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• POLYMORPHIC COMPOUNDS AND USES THEREOF
  申请人：Astrocyte Pharmaceuticals, Inc.

  公开号：US20200093848A1

  公开（公告）日：2020-03-26

  The present invention provides compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.

  本发明提供了化合物及其治疗某些疾病和病况的方法，例如用于治疗脑损伤如中风或创伤性脑损伤的方法。
• Compounds and methods for treating neurological and cardiovascular conditions
  申请人：Astrocyte Pharmaceuticals, Inc.

  公开号：US10265338B2

  公开（公告）日：2019-04-23

  The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.

  本发明涉及用于治疗某些疾病和病症（例如脑损伤，如中风或脑外伤）的化合物及其使用方法。
• Polymorphic compounds and uses thereof
  申请人：Astrocyte Pharmaceuticals, Inc.

  公开号：US10765693B2

  公开（公告）日：2020-09-08

  The present invention provides compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.

  本发明提供了用于治疗某些疾病和病症（例如脑损伤，如中风或脑外伤）的化合物及其使用方法。
• COMPOUNDS AND METHODS FOR TREATING NEUROLOGICAL AND CARDIOVASCULAR CONDITIONS
  申请人：Astrocyte Pharmaceuticals, Inc.

  公开号：US20180021363A1

  公开（公告）日：2018-01-25

  The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
• COMPOUNDS AND METHODS FOR TREATING ADDICTION AND RELATED DISORDERS
  申请人：Astrocyte Pharmaceuticals, Inc.

  公开号：US20210030760A1

  公开（公告）日：2021-02-04

  The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example an addiction or compulsive disorder.