| 1257322-26-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1257322-26-1
• 化学式: C₂₁H₁₈ClN₃O₂
• 分子量: 379.846
• InChiKey: VGVFTCSPCZWTFJ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 甲基磺酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到
  参考文献：
  名称：

  Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors

  摘要：

  The synthesis and SAR of aminomethyl-substituted imidazolopyrimidine DPP4 inhibitors bearing varied pendant aryl groups is described. Compound 1, which exists as a separable mixture of non-interconvertible atropisomers was used as the starting point for investigation. The effects of substituent pattern and type as well as stereochemical effects on inhibitor potency are discussed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.08.090
• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors

  摘要：

  The synthesis and SAR of aminomethyl-substituted imidazolopyrimidine DPP4 inhibitors bearing varied pendant aryl groups is described. Compound 1, which exists as a separable mixture of non-interconvertible atropisomers was used as the starting point for investigation. The effects of substituent pattern and type as well as stereochemical effects on inhibitor potency are discussed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.08.090