4-diethylamino-1-(4-methoxy-phenyl)-butan-1-one | 855221-37-3

• 英文名称: 4-diethylamino-1-(4-methoxy-phenyl)-butan-1-one
• 英文别名: 4-Diaethylamino-1-(4-methoxy-phenyl)-butan-1-on；4-(Diethylamino)-1-(4-methoxyphenyl)butan-1-one
• CAS: 855221-37-3
• 化学式: C₁₅H₂₃NO₂
• 分子量: 249.353
• InChiKey: HBMDQPGPIULPAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-diethylamino-1-(4-methoxy-phenyl)-butan-1-one 在 氢溴酸 、 溶剂黄146 作用下， 反应 11.0h， 生成 4-(diethylamino)-1-(4-hydroxyphenyl)butan-1-one
  参考文献：
  名称：

  2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: A study on the importance of modifications at the side chain on the activity

  摘要：

  As a part of our project aimed at developing new agents of potential application in AD, a new series of 2-phenoxy-indan-1-one derivatives which possess alkylamine side chain were designed, synthesized and evaluated for their inhibitory activity against AChE and BuChE. Most of the compounds were found to inhibit AChE in the nanomolar range. The optimum inhibitor 3g exhibited 34-fold increase in AChE inhibition than donepezil and displayed neuroprotective effect against H2O2-induced cell death. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.014
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 4-diethylamino-1-(4-methoxy-phenyl)-butan-1-one
  参考文献：
  名称：

  Synthesis of Quinacrine Analogs Having Aromatic Groups in the Side Chain¹

  摘要：

  DOI：

  10.1021/ja01225a018