(S)-2-((R)-2-hydroxy-2-methyl-1-phenylpropylamino)-N,N,3-trimethylbutanamide | 1352966-66-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-((R)-2-hydroxy-2-methyl-1-phenylpropylamino)-N,N,3-trimethylbutanamide
• 英文别名: (2S)-2-[[(1R)-2-hydroxy-2-methyl-1-phenylpropyl]amino]-N,N,3-trimethylbutanamide
• CAS: 1352966-66-5
• 化学式: C₁₇H₂₈N₂O₂
• 分子量: 292.422
• InChiKey: AJPDQNBOEVHTLO-LSDHHAIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (S,E)-2-(benzylideneamino)-N,N,3-trimethylbutanamide 在 四丁基氟化铵 、 四丁基高氯酸铵 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 生成 (S)-2-((R)-2-hydroxy-2-methyl-1-phenylpropylamino)-N,N,3-trimethylbutanamide 、 (S)-2-((S)-2-hydroxy-2-methyl-1-phenylpropylamino)-N,N,3-trimethylbutanamide
  参考文献：
  名称：

  Diastereoselective intermolecular coupling of chiral α-imino amides with ketones by electroreduction

  摘要：

  The electroreductive intermolecular coupling of chiral alpha-imino N,N-dialkylamides derived from (S)-alpha-amino N,N-dialkylamides and aromatic aldehydes with ketones in the presence of chlorotrimethylsilane and triethylamine gave beta-amino alcohols with moderate to good (R)-stereoselectivity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.10.022

文献信息

• Diastereoselective intermolecular coupling of chiral α-imino amides with ketones by electroreduction
  作者：Naoki Kise、Aiko Yamane、Shingo Nakao、Akiko Takebe、Toshihiko Sakurai

  DOI：10.1016/j.tetasy.2011.10.022

  日期：2011.11

  The electroreductive intermolecular coupling of chiral alpha-imino N,N-dialkylamides derived from (S)-alpha-amino N,N-dialkylamides and aromatic aldehydes with ketones in the presence of chlorotrimethylsilane and triethylamine gave beta-amino alcohols with moderate to good (R)-stereoselectivity. (C) 2011 Elsevier Ltd. All rights reserved.