phenyl 4-fluoro-4-nitro-4-phenylbutanoate | 1423065-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: phenyl 4-fluoro-4-nitro-4-phenylbutanoate
• 英文别名: Phenyl 4-fluoro-4-nitro-4-phenylbutanoate
• CAS: 1423065-70-6
• 化学式: C₁₆H₁₄FNO₄
• 分子量: 303.29
• InChiKey: NTBOIBMPWBIVGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-fluoro-1-phenylnitromethane 、 丙烯酸苯酯 在 [RuH2(PPh3)4] 作用下， 以 乙腈 为溶剂， 反应 22.0h， 以87%的产率得到phenyl 4-fluoro-4-nitro-4-phenylbutanoate
  参考文献：
  名称：

  [RuH2(PPh3)4]-Catalyzed Michael Addition Reaction of α-Fluoronitroalkanes

  摘要：

  The Michael addition reactions of alpha-fluoronitroalkanes with various electron-deficient olefins were realized by catalysis of low-valence ruthenium species through C-sp3-H activation, providing a useful way to construct a fluorinated quaternary carbon center. The reactions were carried out under neutral conditions, affording the desired products in moderate to excellent yields.

  DOI：

  10.1055/s-0032-1317526

文献信息

• [RuH2(PPh3)4]-Catalyzed Michael Addition Reaction of α-Fluoronitroalkanes
  作者：Xianjin Yang、Yong Guo、Qi Wang、Qing-Yun Chen

  DOI：10.1055/s-0032-1317526

  日期：——

  The Michael addition reactions of alpha-fluoronitroalkanes with various electron-deficient olefins were realized by catalysis of low-valence ruthenium species through C-sp3-H activation, providing a useful way to construct a fluorinated quaternary carbon center. The reactions were carried out under neutral conditions, affording the desired products in moderate to excellent yields.