1-ethyl-6-fluoro-1H-indole-2-carboxylic acid | 1240571-99-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-ethyl-6-fluoro-1H-indole-2-carboxylic acid
• 英文别名: 1-ethyl-6-fluoroindole-2-carboxylic acid
• CAS: 1240571-99-6
• 化学式: C₁₁H₁₀FNO₂
• 分子量: 207.204
• InChiKey: SHYFQKDFTNPSPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS<br/>[FR] DÉRIVÉS DE BENZOIMIDAZOLE EN TANT QU'INHIBITEURS DE PAD4
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2016185279A1

  公开（公告）日：2016-11-24

  Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

  式(I)的化合物：其中X、Y、R1和R3-R11如本文所定义，并其盐为PAD4抑制剂，可能在治疗各种疾病中有用，例如类风湿关节炎、血管炎、系统性红斑狼疮、溃疡性结肠炎、癌症、囊性纤维化、哮喘、皮肤红斑狼疮和牛皮癣。
• [EN] PYRAZOLE COMPOUNDS AS CRTH2 ANTAGONISTS<br/>[FR] COMPOSÉS DE PYRAZOLE EN TANT QU'ANTAGONISTES DE CRTH2
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2012101043A1

  公开（公告）日：2012-08-02

  The present invention relates to pyrazole compounds of formula (1a) or (1b) and pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Y1, y2, y3, y4, y5, Z, R1, R2, n and R3 have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical formulation containing said compounds and to pharmaceutical formulations said compounds in combination with one or more active substances. The compounds have CRTH2 antagonistic activity.

  本发明涉及化学式（1a）或（1b）的吡唑化合物及其药学上可接受的盐，其中Ra、Rb、Rc、Rd、Y1、y2、y3、y4、y5、Z、R1、R2、n和R3具有规范和声明中指示的含义之一，以及它们作为药物的用途，含有所述化合物的药物配方，以及含有所述化合物与一个或多个活性物质组合的药物配方。这些化合物具有CRTH2拮抗活性。
• Pyrazole Compounds as CRTH2 Antagonists
  申请人：Anderskewitz Ralf

  公开号：US20130023576A1

  公开（公告）日：2013-01-24

  Pyrazole compounds of formula (Ia) or (Ib) and pharmaceutically acceptable salts thereof, wherein R a , R b , R c , R d , Y 1 , Y 2 , Y 3 , Y 4 , Y 5 , Z, R 1 , R 2 , n and R 3 have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical formulations containing the compounds and to pharmaceutical formulations containing the compounds in combination with one or more active substances.

  化学式（Ia）或（Ib）的吡唑化合物及其药用盐，其中Ra、Rb、Rc、Rd、Y1、Y2、Y3、Y4、Y5、Z、R1、R2、n和R3具有规范和索赔中指示的含义之一，用作药物，含有该化合物的药物配方，以及含有该化合物与一个或多个活性物质结合的药物配方。
• Benzoimidazole derivatives as PAD4 inhibitors
  申请人：GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

  公开号：US10407407B2

  公开（公告）日：2019-09-10

  Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

  式（I）：其中 X、Y、R1 和 R3-R11 如本文所定义的化合物及其盐类是 PAD4 抑制剂，可用于治疗各种疾病，例如类风湿性关节炎、血管炎、系统性红斑狼疮、溃疡性结肠炎、癌症、囊性纤维化、哮喘、皮肤红斑狼疮和银屑病。
• INDOLE DERIVATIVE, PREPARATION METHOD THEREOF, AND USE THEREOF IN PHARMACEUTICAL DRUG
  申请人：Zhejiang Hisun Pharmaceutical Co., Ltd

  公开号：EP3339305B1

  公开（公告）日：2022-05-04