ethyl 1-(2-ethoxyethyl)-2,4-dioxocyclohexanecarboxylate | 1387584-51-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 1-(2-ethoxyethyl)-2,4-dioxocyclohexanecarboxylate
• CAS: 1387584-51-1
• 化学式: C₁₄H₂₀O₆
• 分子量: 284.309
• InChiKey: OQNVJTPHMULBCA-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  乙酰乙酸乙酯 、 丙烯酸乙酯 在 sodium hydride 作用下， 反应 1.0h， 以64%的产率得到ethyl 1-(2-ethoxyethyl)-2,4-dioxocyclohexanecarboxylate
  参考文献：
  名称：

  Consecutive Michael-Claisen Process for Cyclohexane-1,3-dione Derivative (CDD) Synthesis from Unsubstituted and Substituted Acetone

  摘要：

  A long-existing problem of cyclohexane-1,3-dione derivatives (CDD) synthesis from unreactive acetone through consecutive Michael-Claisen process was solved under this study. The practical applicability of this process was tested for a novel compound ethyl 3-(2,4-dioxocyclohexyl) propanoate for up to 20-gram scale. Furthermore, the scope of different acetone derivatives was investigated and resulted with similar consecutive Michael-Claisen process for CDD synthesis. The reaction exhibited remarkable regioselectivity in Michael addition followed by Claisen cyclization. In this process high substrate selectivity was observed for CDD synthesis following consecutive double-Michael-Claisen and Michael-Claisen cyclization.

  DOI：

  10.1055/s-0031-1290900