2-(5,5-dimethyl-2-(8-morpholino-2,3-dihydrobenzo[b][1,4]dioxin-5-ylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide | 1384860-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-(5,5-dimethyl-2-(8-morpholino-2,3-dihydrobenzo[b][1,4]dioxin-5-ylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide
• 英文别名: 2-[[5,5-dimethyl-2-[(5-morpholin-4-yl-2,3-dihydro-1,4-benzodioxin-8-yl)amino]-6,7-dihydropyrrolo[2,3-d]pyrimidin-4-yl]amino]-N-methylbenzamide
• CAS: 1384860-67-6
• 化学式: C₂₈H₃₃N₇O₄
• 分子量: 531.615
• InChiKey: GHSLKCOUNKIRQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS
  申请人：Xiao Dengming

  公开号：US20130281438A1

  公开（公告）日：2013-10-24

  The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/or Pyk2 mediated disorder or disease.

  本发明涉及一种新型的2,4-二氨基-6,7-二氢-5H-吡咯[2,3]嘧啶衍生物，作为FAK和/或Pyk2抑制剂，以及它们的制备方法、组合物和化合物用于抑制FAK和/或Pyk2以及治疗FAK和/或Pyk2介导的疾病或疾病的方法。
• SMALL MOLECULE COMPOUNDS FOR TARGETING INFLAMMATORY CONDITIONS
  申请人：Brooks Marvin B.

  公开号：US20130281448A1

  公开（公告）日：2013-10-24

  Provided herein are small molecule compounds for the treatment of inflammatory conditions, and pharmaceutical compositions and methods relating thereto. For example, provided herein are compositions comprising small molecule compounds for the treatment of conditions such as multiple sclerosis, type 2 diabetes, psoriasis, rheumatoid arthritis, Hashimoto's thyroiditis, and Crohn's disease. In some embodiments, the pharmaceutical composition and methods described herein pertain to small molecule compounds previously known for the treatment of another condition, such as non-small-cell lung cancer (NSCLC).
• US9428508B2
  申请人：——

  公开号：US9428508B2

  公开（公告）日：2016-08-30