3-amino-octanoic acid ethyl ester | 56266-10-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-amino-octanoic acid ethyl ester
• 英文别名: 3-Amino-octansaeure-aethylester；ethyl 3-aminooctanoate
• CAS: 56266-10-5
• 化学式: C₁₀H₂₁NO₂
• 分子量: 187.282
• InChiKey: CEDSNFJYOFAYHK-UHFFFAOYSA-N

物化性质

• 沸点：
  132-133 °C(Press: 25 Torr)
• 密度：
  0.931±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-amino-octanoic acid ethyl ester 、 乙醛 在 乙醇 、 铂 作用下， 生成 3-ethylamino-octanoic acid ethyl ester
  参考文献：
  名称：

  Decombe, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1930, vol. 191, p. 947

  摘要：

  DOI：
• 作为产物：
  描述：

  苯甲酰肼 、 3-氧代辛酸乙酯 在 乙醇 作用下， 生成 3-amino-octanoic acid ethyl ester
  参考文献：
  名称：

  Decombe, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1930, vol. 190, p. 270

  摘要：

  DOI：

文献信息

• Novel dioctatin derivatives and production process thereof
  申请人：Muraoka Yasuhiko

  公开号：US20080312080A1

  公开（公告）日：2008-12-18

  To provide dioctatin derivatives, a production process thereof, an aflatoxin production inhibitor containing the dioctatin derivative, and a method of controlling aflatoxin contamination by use of the aflatoxin production inhibitor containing the dioctatin derivative. The present invention provides dioctatin derivatives represented by the following Structural Formula (I): where R 1 and R 2 each represent CH 3 —(CH 2 ) n —, (CH 3 ) 2 CH—CH 2 — or C 6 H 5 —CH 2 —; n represents an integer of 2 to 6; X 1 and X 2 each represent CH 3 or hydrogen atom; and Y represents 2-amino-2-butenoic acid or amino acid residue, with compounds where R 1 and R 2 are each CH 3 (CH 2 ) 4 —, X 2 is a hydrogen atom and Y is 2-amino-2-butenoic acid being excluded.

  提供二辛酸衍生物、其生产工艺、含有二辛酸衍生物的黄曲霉毒素生产抑制剂，以及利用含有二辛酸衍生物的黄曲霉毒素生产抑制剂控制黄曲霉素污染的方法。本发明提供了由以下结构式（I）表示的二辛酸衍生物： 其中R1和R2分别代表CH3—(CH2)n—、(CH3)2CH—CH2—或C6H5—CH2—；n代表2至6的整数；X1和X2分别代表CH3或氢原子；Y代表2-氨基-2-丁烯酸或氨基酸残基，其中排除了R1和R2均为CH3(CH2)4—、X2为氢原子且Y为2-氨基-2-丁烯酸的化合物。
• Aflatoxin Production Inhibitor and Method for Controlling Aflatoxin Contamination Using the Same
  申请人：Sakuda Shohei

  公开号：US20100063150A1

  公开（公告）日：2010-03-11

  An object of the present invention is to provide an aflatoxin production inhibitor that inhibits aflatoxin production specifically and efficiently, is highly safe, and is practical, and an efficient production method thereof; and a method for controlling aflatoxin contamination that uses the aflatoxin production inhibitor. Specifically, the present invention relates to an aflatoxin production inhibitor that includes at least one of a dioctatin represented by the following formula (I) and a derivative thereof, as an active ingredient: where, in the formula (I), R represents one of hydrogen and a methyl group. The present invention also relates to a method for producing an aflatoxin production inhibitor in which dioctatin is prepared: by a method including culturing a dioctatin-producing microorganism, and at least one of separating and purifying dioctatin from a culture obtained, by centrifugal liquid liquid partition chromatography; or by chemical synthesis. Further, the present invention relates to a method for controlling aflatoxin contamination that includes using the aflatoxin production inhibitor to thereby inhibit aflatoxin production by an aflatoxin-producing microorganism.

  本发明的目的是提供一种特异性和高效的黄曲霉毒素生产抑制剂，具有高度安全性和实用性，以及其有效的生产方法；以及使用黄曲霉毒素生产抑制剂的控制黄曲霉毒素污染的方法。具体而言，本发明涉及一种黄曲霉毒素生产抑制剂，其包括下式（I）所表示的二氧化锡类及其衍生物中的至少一种作为活性成分：其中，在式（I）中，R表示氢或甲基之一。本发明还涉及一种制备二氧化锡类的黄曲霉毒素生产抑制剂的方法：通过培养生产二氧化锡类的微生物，并通过离心液液分配色谱法从所得到的培养物中分离和纯化二氧化锡类中的至少一种；或通过化学合成。此外，本发明还涉及一种使用黄曲霉毒素生产抑制剂来抑制黄曲霉毒素生产的黄曲霉毒素生产控制方法。
• 3-Amino-3-arylpropionic acid n-alkyl esters, process for production thereof, and process for production of optically active 3-amino-3-arylpropionic acids and esters of the antipodes thereto
  申请人：Yamamoto Yasuhito

  公开号：US20060178433A1

  公开（公告）日：2006-08-10

  The present invention is to provide an n-alkyl 3-amino-3-arylpropionate represented by the formula (I): wherein Ar 1 represents an aryl group which may have a substituent(s), provided that a phenyl group and 4-methoxyphenyl group are excluded, R 1 represents an n-propyl group or an n-butyl group, and a process for preparing the same, and its optically active compound and an optically active (S or R)-3-amino-3-arylpropionic acid represented by the formula (III-a): wherein Ar represents an aryl group which may have a substituent(s), and * represents an asymmetric carbon, and a process for preparing an optically active n-alkyl (R or S)-3-amino-3-arylpropionate represented by the formula (IV-a): wherein Ar and R 1 have the same meanings as defined above, * represents an asymmetric carbon, provided that it has a reverse absolute configuration to the compound of the formula (III-a).

  本发明提供了一种n-烷基3-氨基-3-芳基丙酸酯，其化学式表示为(I)：其中，Ar1表示一个芳基基团，可以具有一个或多个取代基，但不包括苯基和4-甲氧基苯基；R1表示一个n-丙基基团或n-丁基基团。本发明还提供了制备该化合物的方法，以及其光学活性化合物和光学活性(S或R)-3-氨基-3-芳基丙酸的化学式表示为(III-a)：其中，Ar表示一个芳基基团，可以具有一个或多个取代基，*表示一个不对称碳，以及制备光学活性n-烷基(R或S)-3-氨基-3-芳基丙酸酯的方法，其化学式表示为(IV-a)：其中，Ar和R1的含义与上述定义相同，*表示一个不对称碳，但其绝对构型与化合物的化学式(III-a)相反。
• Processes For Preparing Optically Active (S Or R-)-Beta-Amino Acid And Optically Active (R Or S)-Beta-Amino Acid Ester, And Beta-Amino Acid 2-Alkoxyethyl Ester And Optically Active (S Or R)-Beta Amino Acid 2-Alkoxyethyl Ester
  申请人：Konegawa Tadayoshi

  公开号：US20080038785A1

  公开（公告）日：2008-02-14

  The present invention relates to a process for preparing an optically active (S or R)-β-amino acid represented by the formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, aryl group or heteroaryl group each of which may have a substituent(s), and * represents an asymmetric carbon atom, and an optically active (R or S)-β-amino acid ester represented by the formula (III): wherein R has the same meaning as defined above, R 1 represents an alkyl group which may have a substituent(s), and * represents an asymmetric carbon atom, provided that it has a reverse absolute configuration to that of the compound of the formula (II), which comprises selectively hydrolyzing water and one of enantiomers of a β-amino acid ester represented by the formula (I): wherein R and R 1 have the same meanings as defined above, which is a racemic mixture, in the presence of a hydrolase in an organic solvent.

  本发明涉及一种制备光学活性的(S或R)-β-氨基酸的过程，其表示为公式(II)：其中R表示一种可以具有取代基的烷基、烯基、炔基、环烷基、芳基、芳基烷基或杂环芳基，*表示一个不对称碳原子，以及一种光学活性的(R或S)-β-氨基酸酯，其表示为公式(III)：其中R具有上述定义的相同含义，R1表示一种可以具有取代基的烷基，*表示一个不对称碳原子，前提是它具有与公式(II)化合物相反的绝对构型，其包括在有机溶剂中，在水和公式(I)表示的β-氨基酸酯的对映体之一中选择性水解，其中R和R1具有上述定义的相同含义，它是一个外消旋混合物，存在水解酶。
• Process for preparing carboxylic acid using surfactant-modified enzyme
  申请人：Miyata Hiroyuki

  公开号：US20090117626A1

  公开（公告）日：2009-05-07

  The present invention relates to a process for preparing a carboxylic acid using a surfactant-modified enzyme which comprises selectively reacting water and a carboxylic acid ester, provided that triglyceride is excluded, in an organic solvent in the presence of a surfactant-modified enzyme.

  本发明涉及一种使用表面活性剂修饰的酶制备羧酸的过程，包括在有机溶剂中，在表面活性剂修饰的酶的存在下，选择性地反应水和羧酸酯，但排除甘油三酯。