4-pentylnonyl 8-[4-(dimethylamino)butyl[8-oxo-8-(4-pentylnonoxy)octyl]amino]octanoate | 1443009-78-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-pentylnonyl 8-[4-(dimethylamino)butyl[8-oxo-8-(4-pentylnonoxy)octyl]amino]octanoate
• 英文别名: 4-Pentylnonyl 8-[4-(dimethylamino)butyl-[8-oxo-8-(4-pentylnonoxy)octyl]amino]octanoate
• CAS: 1443009-78-6
• 化学式: C₅₀H₁₀₀N₂O₄
• 分子量: 793.355
• InChiKey: OZDAINLVUABNNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.7
• 重原子数：
  56
• 可旋转键数：
  47
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 4-pentylnonyl 8-[4-aminobutyl-[8-oxo-8-(4-pentylnonoxy)octyl]amino]octanoate hydrochloride 在 碳酸氢钠 、 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 以87 mg的产率得到4-pentylnonyl 8-[4-(dimethylamino)butyl[8-oxo-8-(4-pentylnonoxy)octyl]amino]octanoate
  参考文献：
  名称：

  [EN] NOVEL IONIZABLE LIPIDS AND LIPID NANOPARTICLES AND METHODS OF USING THE SAME
  [FR] NOUVEAUX LIPIDES IONISABLES ET NANOPARTICULES LIPIDIQUES ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  Novel ionizable lipids and lipid nanoparticles that can be used in the delivery of therapeutic cargos are disclosed.

  公开号：

  WO2023091490A1

文献信息

• LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20140308304A1

  公开（公告）日：2014-10-16

  The present invention relates to novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
• [EN] LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS<br/>[FR] LIPIDES POUR L'ADMINISTRATION D'AGENTS ACTIFS
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2013086373A1

  公开（公告）日：2013-06-13

  The present invention relates to novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.