2,5-bis(4-hydroxyphenyl)pyridine | 155266-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,5-bis(4-hydroxyphenyl)pyridine
• 英文别名: 2,5-Di(4-hydroxyphenyl)pyridine；2,5-Bis(4-hydroxyphenyl)pyridine；4-[6-(4-hydroxyphenyl)pyridin-3-yl]phenol
• CAS: 155266-51-6
• 化学式: C₁₇H₁₃NO₂
• 分子量: 263.296
• InChiKey: GBBJAGDMZTWZBP-UHFFFAOYSA-N

物化性质

• 熔点：
  155 °C
• 沸点：
  493.0±35.0 °C(Predicted)
• 密度：
  1.253±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,5-bis(4-hydroxyphenyl)pyridine 在 三溴化硼 、 caesium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 2-(4-{5-[4-(2-Hydroxy-ethoxy)-phenyl]-pyridin-2-yl}-phenoxy)-ethanol
  参考文献：
  名称：

  Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity

  摘要：

  A series of 2,5- and 3,5-diphenylpyridine derivatives was synthetised in high yields. A versatile chemical strategy allows the design of diphenylpyridines differently substituted with cationic or neutral side chains. The interaction of the molecules with DNA was investigated by biophysical and biochemical methods and an AT-binder (20) was characterised. A few cytotoxic molecules were identified but their antiproliferative activity does not correlate with DNA binding. Two compounds 18 and 22 showed significant antiproliferative activity and provide a novel route to potential anticancer agents. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.04.011
• 作为产物：
  描述：

  2,5-双(4-甲氧基苯基)吡啶 在 吡啶盐酸盐 作用下， 反应 5.0h， 生成 2,5-bis(4-hydroxyphenyl)pyridine
  参考文献：
  名称：

  钯(II)的多链二苯基吡啶配合物的液晶和发光性质

  摘要：

  多链状 2,5-二苯基吡啶配体的钯配合物由 (NH 4 ) 2 [PdCl 4 ] 在两阶段反应中制备；报告和讨论了它们的液晶和发射特性。对于四链和六链衍生物，配体和它们的配合物都不是液晶的。三链配体仅显示由纹影纹理识别的 SmC 相。tricatenar 和 dicatenar 配体的钯化导致复合物显示出 SmA 相，其范围取决于配体。中间相的身份由小角 X 射线散射 (SAXS) 支持。所有配体和配合物都表现出发光特性，配合物的发射寿命表明不存在磷光。

  DOI：

  10.1016/j.jorganchem.2022.122455

文献信息

• LUMINOPHORES
  申请人：Bruce Duncan W.

  公开号：US20130137869A1

  公开（公告）日：2013-05-30

  There is described a non-planar iridium-ligand complex with accessible triplet states and a molecular structure that confers liquid-crystal like properties.

  描述了一种非平面的铱配体复合物，具有可访问的三重态状态和分子结构，赋予其类似液晶的性质。
• Development and characterization of novel proton conducting aromatic polyether type copolymers bearing main and side chain pyridine groups
  申请人：Geormezi Maria

  公开号：US20080070093A1

  公开（公告）日：2008-03-20

  Featured are novel heterocycle substituted hydroquinones, aromatic copolymers and homopolymers bearing main and side chain polar pyridine units. These polymers exhibit good mechanical properties, high thermal and oxidative stability, high doping ability and high conductivity values. These novel polymers can be used in the preparation and application of MEA on PEMFC type single cells. The combination of the above mentioned properties indicate the potential of the newly prepared materials to be used as electrolytes in high temperature PEM fuel cells.

  本文介绍了一种新型的杂环取代的对苯二酚、含有主链和侧链极性吡啶单元的芳香族共聚物和均聚物。这些聚合物具有良好的机械性能、高热稳定性和氧化稳定性、高掺杂能力和高电导率。这些新型聚合物可以用于制备和应用于PEMFC类型的单个电池上的MEA。上述性质的组合表明，新制备的材料具有作为高温PEM燃料电池电解质的潜力。
• Polyethersulfone compositions
  申请人：Moore Roger David

  公开号：US20060030683A1

  公开（公告）日：2006-02-09

  Novel polyethersulfone compositions have been discovered which incorporate structural subunits derived from sulfonated bis(halophenyl)sulfones, dihydroxy terphenyls, and/or bis(hydroxyphenyl)pyridines. The sulfonated polyethersulfones show promise as materials for use in polymer electrolyte membranes (PEMs) in fuel cells owing to their high proton conductivities (0.02-0.07 S/cm at 20° C. and 100 percent humidity). In addition, a novel unsulfonated thermoplastic polyethersulfone comprising structural subunits derived from a non-sulfonated bis(halophenyl)sulfone bis4-fluorophenyl)sulfone and 4,4′-dihydroxyphenyl-2,6-pyridine (CAS No. 171820-16-9) is disclosed.

  人们发现了新型聚醚砜组合物，其中包含的结构单元来自磺化双（卤苯基）砜、二羟基三联苯和/或双（羟基苯基）吡啶。磺化聚醚砜具有很高的质子传导性（在 20° C 和 100% 湿度条件下为 0.02-0.07 S/cm），因此有望用作燃料电池中的聚合物电解质膜（PEM）材料。此外，还公开了一种新型非磺化热塑性聚醚砜，该聚醚砜由衍生自非磺化双（卤苯基）砜双4-氟苯基）砜和 4,4′-二羟基苯基-2,6-吡啶（化学文摘社编号：171820-16-9）的结构单元组成。
• Synthesis of dihydroxyoligophenylenes containing π-deficient or π-excess hetero-aromatic rings and their solvatochromic behavior
  作者：Isao Yamaguchi、Kenji Seo、Yukari Kawashima

  DOI：10.1016/j.tet.2010.06.087

  日期：2010.8

  Dihydroxyoligophenylenes (HO-ArPh(m)-OHs) with 9,9-dihexy1-2,7-fluorene (Ar=Flu), 2,5-dioctyloxy-1,4-benzene (Ar=Dob), pyridine (Ar=Py), or thiophene (Ar=Th) rings were synthesized by the Suzuki coupling reaction. Absorption maxima (lambda(max)) of HO-ArPh(m)-OHs shifted progressively toward long wavelengths due to the expansion of the it-conjugation system with an increase in the number of benzene rings. Deprotonation of the OH groups of HO-ArPh(m)-OHs by treatment with NaH caused a bathochromic shift of lambda(max). The bathochromic shift of the deprotonated species increased with the donor numbers (DNs) of the solvents. The emission peak positions of NaO-ArPh(m)-ONas depended on the DNs of the solvents; therefore, the emission color could be tuned by changing the solvent. (C) 2010 Elsevier Ltd. All rights reserved.
• PROTON CONDUCTING AROMATIC POLYETHER POLYMERS WITH PYRIDINYL SIDE CHAINS FOR FUEL CELLS
  申请人：Advent Technologies

  公开号：EP2089377B1

  公开（公告）日：2013-04-10