methyl 7-fluoroenanthate | 353-10-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 7-fluoroenanthate
• 英文别名: 7-fluoro-heptanoic acid methyl ester；7-Fluor-heptansaeure-methylester；Methyl 7-fluoroheptanoate
• CAS: 353-10-6
• 化学式: C₈H₁₅FO₂
• 分子量: 162.204
• InChiKey: AXMRETOOLINYDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 7-fluoroenanthate 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 [1]naphthyl-carbamic acid-(7-fluoro-heptyl ester)
  参考文献：
  名称：

  Toxic Fluorine Compounds. III.¹ ι-Fluoroalcohols

  摘要：

  DOI：

  10.1021/jo01113a006
• 作为产物：
  描述：

  甲醇 、 7-氟庚酸 在 硫酸 、 1,2-二氯乙烷 作用下， 生成 methyl 7-fluoroenanthate
  参考文献：
  名称：

  Toxic Fluorine Compounds. X.¹ ι-Fluorocarboxylic Acid Chlorides, Anhydrides, Amides, and Anilides

  摘要：

  DOI：

  10.1021/jo01114a017

文献信息

• PREPARATION OF SELECTIVELY FLUORINATED ORGANIC COMPOUNDS
  申请人：F2 Chemicals Limited

  公开号：EP1140734A1

  公开（公告）日：2001-10-10
• [EN] PREPARATION OF SELECTIVELY FLUORINATED ORGANIC COMPOUNDS<br/>[FR] PREPARATION DE COMPOSES ORGANIQUES FLUORES DE MANIERE SELECTIVE
  申请人：F2 CHEMICALS LTD

  公开号：WO2001028959A1

  公开（公告）日：2001-04-26

  The present invention provides a method of selectively fluorinating a carbon-hydrogen bond at an unactivated saturated sp3 hybridised carbon atom of an organic compound, the method including reacting the organic compound with elemental fluorine gas, characterised in that the reaction is carried out in the presence of a basic compound. The method enables the selective transformation of carbon-hydrogen bonds to carbon-fluorine bonds in molecules where the hydrogen atom is attached to a fully saturated unactivated sp3 hybridised carbon atom such as a tertiary carbon atom found in many saturated hydrocarbon compounds and steroid derivatives. Advantageously, the method may be carried out at or just below room temperature.
• Toxic Fluorine Compounds. X.¹ ι-Fluorocarboxylic Acid Chlorides, Anhydrides, Amides, and Anilides
  作者：F. L. M. PATTISON、R. R. FRASER、G. J. O'NEILL、J. F. K. WILSHIRE

  DOI：10.1021/jo01114a017

  日期：1956.8
• Toxic Fluorine Compounds. III.¹ ι-Fluoroalcohols
  作者：F. L. M. PATTISON、W. C. HOWELL、A. J. McNAMARA、J. C. SCHNEIDER、J. F. WALKER

  DOI：10.1021/jo01113a006

  日期：1956.7