| 1350447-74-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1350447-74-3
• 化学式: C₁₇H₂₅NO₄S
• 分子量: 339.456
• InChiKey: MZBGDRJLKZDRNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.74
• 重原子数：
  23.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  63.68
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  在 盐酸羟胺 、 potassium hydroxide 作用下， 以 甲醇 为溶剂， 生成 N-hydroxy-4-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]butanamide
  参考文献：
  名称：

  4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors

  摘要：

  A series of N-substituted 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of histone deacetylase (HDAC) inhibitors (zinc binding moiety-linker-capping group) has been previously reported by our group. Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells.We report here the second part of the strategy used in our research group to find a new class of HDAC inhibitors, namely the SAR study for the compounds bearing a sulfonyl group on the piperidine nitrogen. In the present work, we have considered both sulfonamides and sulfonyl ureas. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.09.042
• 作为产物：
  描述：

  4-哌啶丁酸 在 氯化亚砜 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors

  摘要：

  A series of N-substituted 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of histone deacetylase (HDAC) inhibitors (zinc binding moiety-linker-capping group) has been previously reported by our group. Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells.We report here the second part of the strategy used in our research group to find a new class of HDAC inhibitors, namely the SAR study for the compounds bearing a sulfonyl group on the piperidine nitrogen. In the present work, we have considered both sulfonamides and sulfonyl ureas. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.09.042

文献信息

• Synthesis of 1,3-Dienes via Ligand-Enabled Sequential Dehydrogenation of Aliphatic Acids
  作者：Guangrong Meng、Liang Hu、Hau Sun Sam Chan、Jennifer X. Qiao、Jin-Quan Yu

  DOI：10.1021/jacs.3c03378

  日期：2023.6.21

  products as well as building blocks for chemical synthesis. Developing efficient methods for the synthesis of diverse 1,3-dienes from simple starting materials is therefore highly desirable. Herein, we report a Pd(II)-catalyzed sequential dehydrogenation reaction of free aliphatic acids via β-methylene C–H activation, which enables one-step synthesis of diverse E,E-1,3-dienes. Free aliphatic acids of

  1,3-二烯是生物活性天然产物中的常见支架，也是化学合成的基础材料。因此，非常需要开发从简单起始原料合成多种 1,3-二烯的有效方法。在此，我们报道了一种 Pd(II) 催化的游离脂肪酸通过 β-亚甲基 C–H 活化的连续脱氢反应，该反应能够一步合成多种E,E -1,3-二烯。不同复杂度的游离脂肪酸，包括抗哮喘药物塞曲司特，被发现与报道的方案兼容。考虑到 1,3-二烯的高度不稳定性和缺乏保护策略，在合成后期将脂肪酸脱氢以揭示 1,3-二烯为合成含有此类基序的复杂分子提供了一种有吸引力的策略。