2-(1-methyl-2,3-dihydro-1H-indol-5-yl)acetic acid | 152149-35-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(1-methyl-2,3-dihydro-1H-indol-5-yl)acetic acid
• 英文别名: 2-(1-methyl-2,3-dihydroindol-5-yl)acetic acid
• CAS: 152149-35-4
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: JUGJHCIHYRBATA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS
  申请人：MEDICAL RESEARCH COUNCIL

  公开号：EP1161418A1

  公开（公告）日：2001-12-12
• US5288749A
  申请人：——

  公开号：US5288749A

  公开（公告）日：1994-02-22
• US6765014B1
  申请人：——

  公开号：US6765014B1

  公开（公告）日：2004-07-20
• [EN] TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS
  申请人：——

  公开号：WO1993012754A2

  公开（公告）日：1993-07-08

  [EN] The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
  [FR] La présente invention se rapporte à un composé d'amines de la formule (I) ou un sel pharmaceutique acceptable de celui-ci qui est un antagoniste destiné aux adrénorécepteurs alpha-2 et qui inhibe la fixation de la sérotonine (5-hydroxytryptamine, 5-HT).
• [EN] 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS<br/>[FR] DERIVES DE 1-ACYL-7-NITROINDOLINE, LEUR PREPARATION ET LEUR UTILISATION COMME PRECURSEURS PHOTOLIBERABLES
  申请人：MEDICAL RES COUNCIL

  公开号：WO2000055133A1

  公开（公告）日：2000-09-21

  Photoreleasable compounds comprising a caging moiety linked to an effector moiety represented by structural formula (I) wherein R1 is hydrogen; C1-10 alkyl or substituted alkyl; O(CH2)n-Y; N(COZ)(CH2)mY; or N[(CH2)mY'[(CH2)NY]; R2 and R3 are independently selected from: hydrogen; C1-10 alkyl or substituted alkyl; or R2 and R3 together are cycloalkyl; R4 is hydrogen; C1-10 alkyl or substituted alkyl; phenyl or substituted phenyl; (CH2)nY; or (CH2)mO(CH2)nY; wherein m and n are independently between 1 and 10; Y and Y' are independently selected from hydrogen, CO2H or salts thereof or OPO32-; Z is hydrogen or C¿1-10? alkyl or substituted alkyl; and, X is an effector moiety or a group capable of being coupled or converted to an effector moiety, which are capable of releasing the effector moiety on irradiation, typically by flash irradiation with UV light. The photoreleasable compounds can therefore be used to deliver biologically active effector moieties such as neuroactive amino acids or metal chelators to sites where their activity is required.