tert-butyl (3S,4R,2'S)-4-[1-(tert-butyldiphenylsilyloxy)-3-methyl-2-butylamino]-2-methylhept-6-en-3-ylcarbamate | 1227182-90-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: tert-butyl (3S,4R,2'S)-4-[1-(tert-butyldiphenylsilyloxy)-3-methyl-2-butylamino]-2-methylhept-6-en-3-ylcarbamate
• CAS: 1227182-90-2
• 化学式: C₃₄H₅₄N₂O₃Si
• 分子量: 566.9
• InChiKey: YNOQAQUUIFESKP-OLUZHXLYSA-N

反应信息

• 作为产物：
  描述：

  、 3-溴丙烯 在 cerium(III) chloride heptahydrate 、 锌 作用下， 以 四氢呋喃 为溶剂， 以32%的产率得到tert-butyl (3S,4R,2'S)-4-[1-(tert-butyldiphenylsilyloxy)-3-methyl-2-butylamino]-2-methylhept-6-en-3-ylcarbamate
  参考文献：
  名称：

  Addition of allylzinc to α-amino acid-derived imines: synthesis of diamino alcohols by hydroboration

  摘要：

  Imines obtained by condensation of Z-protected or Boc-protected alpha-amino aldehydes with alpha-amino tert-butyl esters or with O-silyl-protected amino alcohols were reacted with preformed allyl zinc yielding homoallylamines with yields around 50% and selectivities ranging from 50: 50 to 90: 10. Hydroboration of the terminal double bond furnished diamino alcohols with yields up to 97%. The configuration of the substrates was determined by X-ray-crystallographic analysis of a hydroboration product and comparison of physical data.

  DOI：

  10.1007/s00706-009-0239-y