(5S)-(E)-tert-butoxycarbonylamino-2-eth-(Z)-ylidene-6-methyl-hept-3-enoic acid methyl ester | 1250266-12-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5S)-(E)-tert-butoxycarbonylamino-2-eth-(Z)-ylidene-6-methyl-hept-3-enoic acid methyl ester
• CAS: 1250266-12-6
• 化学式: C₁₇H₂₉NO₄
• 分子量: 311.422
• InChiKey: IFHASXLXGVXWPV-KUMFLAMMSA-N

反应信息

• 作为产物：
  描述：

  (E)-methyl α-bromocrotonate 、 [(S)-3-Methyl-1-((E)-2-tributylstannanyl-vinyl)-butyl]-carbamic acid tert-butyl ester 在 四(三苯基膦)钯 作用下， 以 甲苯 为溶剂， 反应 0.75h， 以70%的产率得到(5S)-(E)-tert-butoxycarbonylamino-2-eth-(Z)-ylidene-6-methyl-hept-3-enoic acid methyl ester
  参考文献：
  名称：

  Synthesis of a new family of 2-ethylidene-γ-unsaturated δ-amino esters via microwave activated Stille coupling

  摘要：

  A simple approach to a new family of enantiomerically enriched polyunsaturated t-Boc-protected-delta-amino esters is described, via microwave promoted Stille coupling of (Z)-methyl-2-bromobutenoate with stannylated allylamines. The reaction conditions are mild and selective and disclose a simple way to 1-substituted butenoates of defined geometry.

  DOI：

  10.1007/s00726-009-0392-y