(3R)-3-[[2-(3,4-dimethoxyphenyl)ethyl](5-methylfuran-2-ylmethyl)carbamoyloxy]-1-(4-ethoxycarbonylbutyl)-1-azoniabicyclo[2.2.2]octane formate | 637744-74-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: (3R)-3-[[2-(3,4-dimethoxyphenyl)ethyl](5-methylfuran-2-ylmethyl)carbamoyloxy]-1-(4-ethoxycarbonylbutyl)-1-azoniabicyclo[2.2.2]octane formate
• 英文别名: ethyl 5-[(3R)-3-[2-(3,4-dimethoxyphenyl)ethyl-[(5-methylfuran-2-yl)methyl]carbamoyl]oxy-1-azoniabicyclo[2.2.2]octan-1-yl]pentanoate;formate
• CAS: 637744-74-2
• 化学式: CHO₂*C₃₁H₄₅N₂O₇
• 分子量: 602.725
• InChiKey: GGHQCSITAAQXIT-SUVRUAAESA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  43
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  128
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Quinuclidine derivatives and pharmaceutical compositions containing the same
  申请人：Prat Quinones Maria

  公开号：US20060094751A1

  公开（公告）日：2006-05-04

  Carbamates of formula (I) or pharmaceutically acceptable salts thereof, including quaternary ammonium salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as antagonists of M3 muscarinic receptors.

  本文披露了式（I）的氨甲酰化合物或其药学上可接受的盐，包括式（II）的季铵盐；以及它们的制备过程，包括它们的药物组合物和它们作为M3肌动蛋白受体拮抗剂在治疗中的应用。
• NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
  申请人：Prat Quinones Maria

  公开号：US20090005412A1

  公开（公告）日：2009-01-01

  Carbamates of formula (I) or pharmaceutically acceptable salts thereof, including quaternary ammonium salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as antagonists of M3 muscarinic receptors.

  公开了化学式（I）的氨基甲酸酯或其药学上可接受的盐，包括化学式（II）的季铵盐；以及它们的制备方法、包含它们的制药组合物以及它们作为M3胆碱能受体拮抗剂在治疗中的应用。
• NOVEL QUINUCLIDINE CARBAMATE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
  申请人：QUINONES Maria PRAT

  公开号：US20090054480A1

  公开（公告）日：2009-02-26

  Carbamates of formula (I) or pharmaceutically acceptable salts thereof, including quaternary ammonium salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as antagonists of M3 muscarinic receptors.

  本文披露了式(I)的氨基甲酸酯或其药学上可接受的盐，包括式(II)的季铵盐，以及它们的制备过程、包含它们的制药组合物以及它们作为M3胆碱能受体拮抗剂在治疗中的应用。
• Process for preparing quinuclidinium carbamate derivatives
  申请人：Quinones Maria Prat

  公开号：US20100249420A9

  公开（公告）日：2010-09-30

  A new process for preparing carbamate derivatives having the structure of formula (I) by reacting, in a first step, a compound of formula (II) with a compound of formula (III) and reacting the product of this first step with an acylating agent of formula (V).

  一种制备具有式(I)结构的氨基甲酸酯衍生物的新工艺，包括以下步骤：第一步，将式(II)的化合物与式(III)的化合物反应，然后将第一步的产物与式(V)的酰化剂反应。
• QUINUCLIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：Almirall Prodesfarma AG

  公开号：EP1515968A2

  公开（公告）日：2005-03-23