2-(3-(2-Cyano-6-(3-(trifluoromethyl)phenyl)pyrimidin-4-yl)propylamino)acetamide | 871793-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(3-(2-Cyano-6-(3-(trifluoromethyl)phenyl)pyrimidin-4-yl)propylamino)acetamide
• 英文别名: 2-[3-[2-cyano-6-[3-(trifluoromethyl)phenyl]pyrimidin-4-yl]propylamino]acetamide
• CAS: 871793-98-5
• 化学式: C₁₇H₁₆F₃N₅O
• 分子量: 363.342
• InChiKey: CMOAHEOOGDVZEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile 、 甘氨酰胺 在 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 2-(3-(2-Cyano-6-(3-(trifluoromethyl)phenyl)pyrimidin-4-yl)propylamino)acetamide
  参考文献：
  名称：

  Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: Improving selectivity over hERG

  摘要：

  Several structure-guided optimisation strategies were explored in order to improve the hERG selectivity profile of cathepsin K inhibitor 1, whilst maintaining its otherwise excellent in vitro and in vivo profile. Ultimately, attenuation of c log P and pK(a) properties proved a successful approach and led to the discovery of a potent analogue 23, which, in addition to the desired selectivity over hERG (>1000-fold), displayed a highly attractive overall profile. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.08.101

文献信息

• [EN] 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES<br/>[FR] DERIVES 4-PHENYLE-PYRIMIDINE-2-CARBONITRILE
  申请人：AKZO NOBEL NV

  公开号：WO2005121106A1

  公开（公告）日：2005-12-22

  The invention relates to 4-phenyl-pyrimidine-2-carbonitrile derivatives having the general formula (I) or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives as well as to the use thereof in the preparation of a medicament suitable for the treatment of osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.

  该发明涉及具有通式（I）或其药学上可接受的盐的4-苯基嘧啶-2-羰基衍生物。该发明还涉及包含上述衍生物的药物组合物，以及在制备适用于治疗骨质疏松症、动脉粥样硬化、炎症和免疫性疾病（如类风湿性关节炎）以及神经病理性疼痛（如神经病性疼痛）的药物中的使用。
• 4-Phenyl-Pyrimidine-2-Carbonitrile Derivatives
  申请人：Cai Jiaqiang

  公开号：US20080090813A1

  公开（公告）日：2008-04-17

  The invention relates to 4-phenyl-pyrimidine-2-carbonitrile derivatives having the general formula I wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising the derivatives as well as to the use thereof in the treatment of osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.

  本发明涉及一种具有一般式I的4-苯基嘧啶-2-碳腈衍生物，其中每个取代基的定义如规范和权利要求所述，或其药学上可接受的盐。本发明还涉及包括这些衍生物的制药组合物以及在治疗骨质疏松症、动脉硬化、炎症和免疫性疾病（如类风湿性关节炎）以及慢性疼痛（如神经病性疼痛）中使用它们的用途。
• 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES
  申请人：N.V. Organon

  公开号：EP1758870A1

  公开（公告）日：2007-03-07
• US7589095B2
  申请人：——

  公开号：US7589095B2

  公开（公告）日：2009-09-15