8-O-benzyl 7-O-methyl (7S,8R)-1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate | 362488-94-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-O-benzyl 7-O-methyl (7S,8R)-1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate
• CAS: 362488-94-6
• 化学式: C₁₇H₂₀O₆
• 分子量: 320.342
• InChiKey: NNOLMLVQYWVXOW-UONOGXRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  8-O-benzyl 7-O-methyl (7S,8R)-1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate 在 palladium dihydroxide 氢气 作用下， 以 乙酸乙酯 为溶剂， 以99%的产率得到(+/-)-cis-1,4-dioxaspiro<4.4>nonane-7,8-dicarboxylic acid monomethyl ester
  参考文献：
  名称：

  α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)

  摘要：

  Selective inhibitors of TNF-alpha Converting Enzyme (TACE) based on (1R,2S)-cyclopentyl, (3S,4S)-pyrrolidinyl, and (3R,4S)-tetrahydrofuranyl beta-benzamido hydroxamic acids have been synthesized and evaluated. This study has led to the discovery of novel inhibitors whose profiles include activity against TACE in an enzyme assay, potency in the suppression of LPS-stimulated TNF-alpha in human whole blood, selectivity against a panel of MMPs and oral bioavailability. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.059
• 作为产物：
  描述：

  1-benzyl 2-methyl (1R,2S)-4-oxocyclopentane-1,2-dicarboxylate 、 乙二醇 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 以95%的产率得到8-O-benzyl 7-O-methyl (7S,8R)-1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate
  参考文献：
  名称：

  α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)

  摘要：

  Selective inhibitors of TNF-alpha Converting Enzyme (TACE) based on (1R,2S)-cyclopentyl, (3S,4S)-pyrrolidinyl, and (3R,4S)-tetrahydrofuranyl beta-benzamido hydroxamic acids have been synthesized and evaluated. This study has led to the discovery of novel inhibitors whose profiles include activity against TACE in an enzyme assay, potency in the suppression of LPS-stimulated TNF-alpha in human whole blood, selectivity against a panel of MMPs and oral bioavailability. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.059

文献信息

• α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)
  作者：Gregory R. Ott、Naoyuki Asakawa、Zhonghui Lu、Rui-Qin Liu、Maryanne B. Covington、Krishna Vaddi、Mingxin Qian、Robert C. Newton、David D. Christ、James M. Traskos、Carl P. Decicco、James J.-W. Duan

  DOI：10.1016/j.bmcl.2007.11.059

  日期：2008.1

  Selective inhibitors of TNF-alpha Converting Enzyme (TACE) based on (1R,2S)-cyclopentyl, (3S,4S)-pyrrolidinyl, and (3R,4S)-tetrahydrofuranyl beta-benzamido hydroxamic acids have been synthesized and evaluated. This study has led to the discovery of novel inhibitors whose profiles include activity against TACE in an enzyme assay, potency in the suppression of LPS-stimulated TNF-alpha in human whole blood, selectivity against a panel of MMPs and oral bioavailability. (c) 2007 Elsevier Ltd. All rights reserved.