G-SN38-TBDPS | 946114-19-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: G-SN38-TBDPS
• 英文别名: [(19S)-7-[tert-butyl(diphenyl)silyl]oxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 2-aminoacetate
• CAS: 946114-19-8
• 化学式: C₄₀H₄₁N₃O₆Si
• 分子量: 687.868
• InChiKey: AVWCDLPVKRDIBE-FAIXQHPJSA-N

反应信息

• 作为反应物：
  描述：

  G-SN38-TBDPS 、 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以37.18 %的产率得到
  参考文献：
  名称：

  POLYETHYLENE GLYCOL CONJUGATE DRUG, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

  摘要：

  The disclosure relates to the technical field of medicine, specifically to a polyethylene glycol conjugated drug, a preparation method therefor and use thereof, and relates in particular to a polyethylene glycol conjugated drug represented by formula (I) or a pharmaceutically acceptable salt thereof. The disclosure further relates to a method for preparation of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof in preparation of a medicament.

  公开号：

  US20230073036A1