4-amino butyric acid chloride hydrochloride | 137048-10-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 4-amino butyric acid chloride hydrochloride
• 英文别名: 4-Aminobutanoyl chloride hydrochloride；4-aminobutanoyl chloride;hydrochloride
• CAS: 137048-10-3
• 化学式: C₄H₈ClNO*ClH
• 分子量: 158.028
• InChiKey: RNTMZPWFIRXIMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.91
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  43.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-amino butyric acid chloride hydrochloride 、 十四醇 以 氯仿 为溶剂， 反应 2.0h， 生成 Tetradecyl 4-aminobutanoate;hydrochloride
  参考文献：
  名称：

  Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation

  摘要：

  Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.077
• 作为产物：
  描述：

  4-氨基丁酸盐酸盐 在 氯化亚砜 作用下， 反应 1.0h， 生成 4-amino butyric acid chloride hydrochloride
  参考文献：
  名称：

  Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation

  摘要：

  Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.077

文献信息

• Reducing composition for the permanent deformation of hair containing as
  申请人：L'Oreal

  公开号：US05085860A1

  公开（公告）日：1992-02-04

  A cosmetic composition for the first stage of a permanent deformation of the hair contains, in a cosmetically acceptable vehicle, as a reducing agent, an amino mercaptoalkylamide having the formula ##STR1## wherein A represents the divalent radical, --(CH.sub.2).sub.n -- wherein n is a whole number ranging from 2 to 5, or the divalent radical --(CH.sub.2)--O--(CH.sub.2).sub.2 --, m is 0 or a whole number ranging from 1 to 4, and (i) when m is 0, R.sub.2 represents hydrogen methyl, ethyl, isopropyl, isobutyl, 2-methyl butyl, benzyl, 4-amino butyl, 3-guanidino propyl, 2-methylthio ethyl, carboxymethyl or 2-carboxyethyl, and (ii) when m is a whole number from 1 to 4, R.sub.1 represents hydrogen or lower alkyl having 1-5 carbon atoms, and the salts of the compound of formula I.

  一种用于永久改变头发形态的化妆品组合物，包含以下成分：在一种化妆品可接受的载体中，作为还原剂，含有式为##STR1##的氨基巯基烷酰胺，其中A代表二价基团，--(CH.sub.2).sub.n--，其中n为2至5的整数，或者是二价基团--(CH.sub.2)--O--(CH.sub.2).sub.2--，m为0或1至4的整数，(i)当m为0时，R.sub.2代表氢、甲基、乙基、异丙基、异丁基、2-甲基丁基、苯甲基、4-氨基丁基、3-鸟氨酸基丙基、2-甲硫基乙基、羧甲基或2-羧乙基；(ii)当m为1至4的整数时，R.sub.1代表氢或1至5个碳原子的低级烷基，以及式I化合物的盐。
• US5085860A
  申请人：——

  公开号：US5085860A

  公开（公告）日：1992-02-04
• US5466878A
  申请人：——

  公开号：US5466878A

  公开（公告）日：1995-11-14