| 1224928-28-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1224928-28-2
• 化学式: C₁₇H₁₉NO₅
• 分子量: 317.342
• InChiKey: RNAPOWKPLJEJBT-BONVTDFDSA-N

物化性质

• 沸点：
  432.5±25.0 °C(predicted)
• 密度：
  1.245±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.67h， 以92%的产率得到
  参考文献：
  名称：

  Diastereoselective Synthesis of γ-Phthalimido-β-Hydroxy Esters and N-Protected 4-Amino-1,3-Diols Starting from Natural α-Amino Acids

  摘要：

  An efficient diastereoselective synthesis of gamma-phthalimido-beta-hydroxy esters and N-protected 4-amino-1,3-diols, starting from natural amino acids is described. The key synthetic strategies involve diastereoselective reduction of gamma-phthalimido-beta-keto esters with NaBH4 as hydride reducing. The diastereoselective reduction has been found to be highly selective if carried out in methanol at -78 degrees C. Furthermore, the resulting diastereomeric mixture of the reduced products was successfully and cleanly separated by column chromatography.

  DOI：

  10.2174/157017810790533869
• 作为产物：
  描述：

  、 magnesium monomethyl malonate 以 四氢呋喃 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Diastereoselective Synthesis of γ-Phthalimido-β-Hydroxy Esters and N-Protected 4-Amino-1,3-Diols Starting from Natural α-Amino Acids

  摘要：

  An efficient diastereoselective synthesis of gamma-phthalimido-beta-hydroxy esters and N-protected 4-amino-1,3-diols, starting from natural amino acids is described. The key synthetic strategies involve diastereoselective reduction of gamma-phthalimido-beta-keto esters with NaBH4 as hydride reducing. The diastereoselective reduction has been found to be highly selective if carried out in methanol at -78 degrees C. Furthermore, the resulting diastereomeric mixture of the reduced products was successfully and cleanly separated by column chromatography.

  DOI：

  10.2174/157017810790533869