4-nitro-benzoic acid-(5,6,7,8-tetrahydro-[2]naphthyl ester) | 856087-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitro-benzoic acid-(5,6,7,8-tetrahydro-[2]naphthyl ester)
• 英文别名: 4-Nitro-benzoesaeure-(5,6,7,8-tetrahydro-[2]naphthylester)；6-(4-Nitro-benzoyloxy)-tetralin；Tetralyl-(6)-(4-nitro-benzoat)；ar-2-Tetralol-(p-nitro-benzoat)；5,6,7,8-Tetrahydronaphthalen-2-yl 4-nitrobenzoate；5,6,7,8-tetrahydronaphthalen-2-yl 4-nitrobenzoate
• CAS: 856087-70-2
• 化学式: C₁₇H₁₅NO₄
• 分子量: 297.31
• InChiKey: XQGKZUPONRJFJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.69
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  69.44
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-nitro-benzoic acid-(5,6,7,8-tetrahydro-[2]naphthyl ester) 在 盐酸 、 tin(ll) chloride 作用下， 生成 4-amino-benzoic acid-(5,6,7,8-tetrahydro-[2]naphthyl ester)
  参考文献：
  名称：

  DE414261

  摘要：

  公开号：
• 作为产物：
  描述：

  5,6,7,8-四氢-2-萘酚 生成 4-nitro-benzoic acid-(5,6,7,8-tetrahydro-[2]naphthyl ester)
  参考文献：
  名称：

  关于取代酚的合成

  摘要：

  DOI：

  10.1002/hlca.19470300234

文献信息

• Über eine Synthese von substituierten Phenolen
  作者：V. Prelog、O. Metzler、O. Jeger

  DOI：10.1002/hlca.19470300234

  日期：1947.3.15
• Thoms; Kross, Archiv der Pharmazie, 1927, p. 346
  作者：Thoms、Kross

  DOI：——

  日期：——
• DE414261
  申请人：——

  公开号：——

  公开（公告）日：——
• Potentiation of the Effect of Paclitaxel and Carboplatin by Antioxidant Mixture on Human Lung Cancer H520 Cells
  作者：Ashutosh K. Pathak、Neeta Singh、Neeru Khanna、Vijay G. Reddy、Kedar N. Prasad、Vinod Kochupillai

  DOI：10.1080/07315724.2002.10719244

  日期：2002.10

  Objective: Antioxidants have been shown to enhance the effect of certain chemotherapeutic agents on tumor cells in culture. However, this effect differs depending upon the type of tumor and the drugs. In this study. the objective was to see whether pretreatment with antioxidant mixture could enhance the cytotoxic and apoptotic effect of commonly used chemotherapeutic agents, paclitaxel and carboplatin for the treatment of NSCLC.Methods: Human lung squamous cell carcinoma cell line, H520. was treated with antioxidant mixture (vitamin C, vitamin E and beta carotene), paclitaxel and carboplatin, individually and in combination of different doses in different sequences. Growth inhibition and induction of apoptosis was studied by morphological changes, MTT assay and flow-cytometric analysis.Results: The antioxidant mixture by itself led to 15% apoptosis in H520 cells. Paclitaxel treatment 24 hours prior to carboplatin caused 54% apoptosis, more than that produced by simultaneous treatment with both agents (40%). A statistically significant improvement in the degree of apoptosis, induced by paclitaxel and carboplatin combination, was seen when the cells were pretreated with antioxidant mixture immediately before paclitaxel exposure (70%) or 24 hours before paclitaxel exposure (89%).Conclusion: The data suggests that the apoptotic effects of paclitaxel and carboplatin are enhanced by pretreatment with the antioxidant mixture. Thus, the most promising sequence of these agents, which emerged in this study, was pretreatment with antioxidant Mixture for 24 hours followed by paclitaxel treatment for 24 hours followed by carboplatin exposure for 24 hours.