N-benzoyl-alanine hydrazide | 15366-27-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzoyl-alanine hydrazide
• 英文别名: N-benzoyl-DL-alanine hydrazide；N-Benzoyl-DL-alanin-hydrazid；N-Benzoyl-alanin-hydrazid；Benzoyl-dl-alanin-hydrazid；N-(1-hydrazinyl-1-oxopropan-2-yl)benzamide
• CAS: 15366-27-5
• 化学式: C₁₀H₁₃N₃O₂
• mdl: MFCD00447995
• 分子量: 207.232
• InChiKey: JVBBUSGKRYKFPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  84.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-benzoyl-alanine hydrazide 在 水 、 溶剂黄146 、 sodium nitrite 作用下， 生成 N,N'-bis-(N-benzoyl-alanyl)-hydrazine
  参考文献：
  名称：

  Curtius; v. d. Linden, Journal fur praktische Chemie (Leipzig 1954), 1904, vol. <2> 70, p. 144

  摘要：

  DOI：
• 作为产物：
  描述：

  苯甲酰基-DL-alpha-丙氨酸乙酯 在 乙醚 、 乙醇 、 一水合肼 作用下， 生成 N-benzoyl-alanine hydrazide
  参考文献：
  名称：

  Curtius; v. d. Linden, Journal fur praktische Chemie (Leipzig 1954), 1904, vol. <2> 70, p. 144

  摘要：

  DOI：

文献信息

• Cornforth, Chemistry of Penicillin
  作者：Cornforth

  DOI：——

  日期：——
• Synthesis and Comparison of Antioxidant Properties of Indole-Based Melatonin Analogue Indole Amino Acid Derivatives
  作者：Sibel Suzen、Seyhan Sezen Cihaner、Tulay Coban

  DOI：10.1111/j.1747-0285.2011.01216.x

  日期：2012.1

  Increased levels of reactive oxygen species attributed to oxidative stress have been found to be responsible for the development of some vital diseases such as cardiovascular, neurodegenerative and autoimmune diseases. Recently, it was observed that melatonin is a highly important antioxidant, and melatonin analogues are under investigation to find out improved antioxidant activity. In this study, 14 melatonin ‐based analogue indole amino acid and N‐protected amino acid derivatives were synthesized and elucidated spectrometrically. To investigate the antioxidant activity of the synthesized compounds and to compare with melatonin, butylhydroxytoluene and vitamin E, lipid peroxidation inhibition and 2,2‐diphenyl‐1‐picrylhydrazyl radical‐scavenging activities were tested. The results indicated that the synthesized new indole amino acid derivatives have similar activities to melatonin in 2,2‐diphenyl‐1‐picrylhydrazyl radical‐scavenging activity assay but more potent activities in lipid peroxidation inhibition assay.
• Ceric(IV) ammonium nitrate in the selective conversion of hydrazides to esters
  作者：Bogdan Štefane、Marijan Kočevar、Slovenko Polanc

  DOI：10.1016/s0040-4039(99)00764-9

  日期：1999.6

  Hydrazides were treated with ceric(IV) ammonium nitrate (CAN) in the presence of the appropriate alcohol as a nucleophile to afford esters in good yields. Reactions took place exclusively at the hydrazino moiety even when other sensitive groups were present in either of the partners. (C) 1999 Elsevier Science Ltd, All rights reserved.
• Synthesis and antitumor evaluation of some 1,3,4-oxadiazole-2(3H)-thione and 1,2,4-triazole-5(1H)-thione derivatives
  作者：ChengTao Feng、LingDong Wang、YuGang Yan、Jian Liu、ShaoHua Li

  DOI：10.1007/s00044-010-9544-6

  日期：2012.3

  A series of 1,3,4-oxadiazole-2-thione and 1,2,4-triazole-5-thione derivatives have been successfully synthesized and studied for their antitumor activity. These compounds were prepared from carboxylic acids and chiral aminoacid esters. The prepared compounds were evaluated for their cytotoxicity against cancer in vitro using hydroxyurea (HU) as positive control. A fair number of compounds were found to have significant antitumor activity. To study the molecular basis of interaction and affinity of binding of the target molecules, all the compounds were docked into the ATPase domain of TP-II and tubulin using Schrodinger.
• Gehlen,H.; Blankenstein,G., Justus Liebigs Annalen der Chemie, 1962, vol. 651, p. 128 - 132
  作者：Gehlen,H.、Blankenstein,G.

  DOI：——

  日期：——