11-ddCTP | 260397-89-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: 11-ddCTP
• CAS: 260397-89-5
• 化学式: C₁₈H₃₀N₅O₁₃P₃
• 分子量: 617.383
• InChiKey: OGFMNFZJKKNEIP-GOEBONIOSA-N

物化性质

• 密度：
  1.80±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.17
• 重原子数：
  39.0
• 可旋转键数：
  14.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  285.08
• 氢给体数：
  7.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  、 11-ddCTP 生成
  参考文献：
  名称：

  Synthesis of Aminomethyl- and Bis-Aminomethyl-Fluorescein Energy Transfer Terminators

  摘要：

  Synthesis of aminomethyl and bis-aminomethylfluorescein derived energy transfer terminators is described.

  DOI：

  10.1080/15257770701542579
• 作为产物：
  描述：

  5-(3-amino-1-propynyl)-2',3'-dideoxycytidine-5'-triphosphoric acid 、 2,5-Dioxo-1-pyrrolidinyl 6-aminohexanoate 生成 11-ddCTP
  参考文献：
  名称：

  FOUR COLOR FRET DYE NUCLEOTIDE TERMINATORS FOR DNA SEQUENCING

  摘要：

  The synthesis of four color set of energy transfer-dye terminators (8a-8d) starting from p-iodo-beta -phenylalanine was accomplished and their utility in the sequencing reactions has been evaluated.

  DOI：

  10.1081/ncn-100002348

文献信息

• [EN] NUCLEOTIDE ANALOGUES AND USE THEREOF FOR NUCLEIC ACID SEQUENCING AND ANALYSIS<br/>[FR] ANALOGUES NUCLÉOTIDIQUES ET LEUR UTILISATION POUR LE SÉQUENÇAGE ET L'ANALYSE D'ACIDES NUCLÉIQUES
  申请人：UNIV COLUMBIA

  公开号：WO2019178393A9

  公开（公告）日：2019-10-24
• SYNTHESIS OF NOVEL PIPERIDINYL LINKER BASED ENERGY TRANSFER TERMINATORS AND THEIR POTENTIAL USE IN DNA SEQUENCING
  作者：T. Sudhakar Rao、Satyam Nampalli、Weihong Zhang、Haiguang Xiao、Shiv Kumar

  DOI：10.1081/ncn-200060586

  日期：2005.4.1

  Synthesis of novel piperidinyl linker based ET cassettes and terminators is described. These novel terminators are evaluated in the DNA sequencing experiments using thermostable DNA polymerase.
• Unnatural amino acid derived FRET cassettes, terminators and their DNA sequencing potential
  作者：Satyam Nampalli、Weihong Zhang、T Sudhakar Rao、Haiguang Xiao、Lakshmi P Kotra、Shiv Kumar

  DOI：10.1016/s0040-4039(02)00196-x

  日期：2002.3

  An unnatural, tri-functional amino acid. t-BOC-L-para-amino-phenylalanine (1). was utilized in the design and syntheses of highly efficient FRET cassettes (4-7) and converted them into 2'.3'-dideoxynucleotide terminators (8-11) for investigating DNA sequencing potential coupled with a thermostable DNA polymerase. Thermo Sequenase(TM) II . (C) 2002 Elsevier Science Ltd. All rights reserved.