19-glutaramide-2,7,12,17-tetraphenylporphycene | 1417886-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 19-glutaramide-2,7,12,17-tetraphenylporphycene
• CAS: 1417886-16-8
• 化学式: C₄₉H₃₇N₅O₃
• 分子量: 743.864
• InChiKey: HWWUZLQQKAKGQI-CZRQGETPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.02
• 重原子数：
  57.0
• 可旋转键数：
  9.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  123.76
• 氢给体数：
  4.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 19-glutaramide-2,7,12,17-tetraphenylporphycene 在 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 以54%的产率得到
  参考文献：
  名称：

  Functionalized mesoporous silica nanoparticles with 2,7,12,17-tetraphenylporphycene

  摘要：

  通过胺化纳米粒子与 9-（戊二酸[式：见正文]-琥珀酰亚胺基酯酰胺）-2,7,12,17-四苯基卟吩反应，制备了装饰有 2,7,12,17-四苯基卟吩的介孔二氧化硅纳米粒子。制备的纳米颗粒通过紫外-可见光谱、DLS 和 TEM 进行了表征。

  DOI：

  10.1142/s1088424619500986
• 作为产物：
  描述：

  9-nitro-2,7,12,17-tetraphenylporphycene 在 sodium dithionite 作用下， 以 二氯甲烷 为溶剂， 生成 19-glutaramide-2,7,12,17-tetraphenylporphycene
  参考文献：
  名称：

  Functionalized mesoporous silica nanoparticles with 2,7,12,17-tetraphenylporphycene

  摘要：

  通过胺化纳米粒子与 9-（戊二酸[式：见正文]-琥珀酰亚胺基酯酰胺）-2,7,12,17-四苯基卟吩反应，制备了装饰有 2,7,12,17-四苯基卟吩的介孔二氧化硅纳米粒子。制备的纳米颗粒通过紫外-可见光谱、DLS 和 TEM 进行了表征。

  DOI：

  10.1142/s1088424619500986

文献信息

• Synthesis, Characterization, and Photoinduced Antibacterial Activity of Porphyrin-Type Photosensitizers Conjugated to the Antimicrobial Peptide Apidaecin 1b
  作者：Ryan Dosselli、Cristiano Tampieri、Rubén Ruiz-González、Sonia De Munari、Xavier Ragàs、David Sánchez-García、Montserrat Agut、Santi Nonell、Elena Reddi、Marina Gobbo

  DOI：10.1021/jm301509n

  日期：2013.2.14

  Antimicrobial photodynamic therapy (aPDT) is an emerging treatment for bacterial infections that is becoming increasingly more attractive because of its effectiveness against multi-antibiotic-resistant strains and unlikelihood of inducing bacterial resistance. Among the strategies to enhance the efficacy of PDT against Gram-negative bacteria, the binding to a cationic antimicrobial peptide offers the attractive prospect for improving both the water solubilty and the localization of the photoactive drug in bacteria. In this work we have compared a number of free and apidaecin-conjugated photosensitizers (PSs) differing in structure and charge. Our results indicate that the conjugation of per se ineffective highly hydrophobic PSs to a cationic peptide produces a photosensitizing agent effective against Gram-negative bacteria. Apidaecin cannot improve the phototoxic activity of cationic PSs, which mainly depends on a very high yield of singlet oxygen production in the surroundings of the bacterial outer membrane. Apidaecin-PS conjugates appear most promising for treatment protocols requiring repeated washing after sensitizer delivery.