N-(2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)phenyl)acetamide | 1312162-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-(2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)phenyl)acetamide
• 英文别名: N-[2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]phenyl]acetamide
• CAS: 1312162-42-7
• 化学式: C₂₅H₂₉N₇O₃
• 分子量: 475.55
• InChiKey: WBEIXRAQIMQJAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS
  申请人：Xiao Dengming

  公开号：US20130281438A1

  公开（公告）日：2013-10-24

  The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/or Pyk2 mediated disorder or disease.

  本发明涉及一种新型的2,4-二氨基-6,7-二氢-5H-吡咯[2,3]嘧啶衍生物，作为FAK和/或Pyk2抑制剂，以及它们的制备方法、组合物和化合物用于抑制FAK和/或Pyk2以及治疗FAK和/或Pyk2介导的疾病或疾病的方法。
• POLYETHYLENE HAVING IMPROVED BRANCHING DEGREE DISTRIBUTION
  申请人：Japan Polyethylene Corporation

  公开号：EP2657260A1

  公开（公告）日：2013-10-30

  An object of the present invention is to provide polyethylene having excellent moldability and impact resistance and excellent balance between rigidity and durability, produced using a novel organoaluminum compound-supported chromium catalyst, a method for producing polyethylene, and a hollow plastic molding containing the polyethylene. The polyethylene of the invention is polymerized using a chromium catalyst, and has a weight average molecular weight (Mw) of 30,000 or more at the maximum value in a branching degree distribution curve that shows a molecular weight dependency of short chain branches having 4 or more carbon atoms.

  本发明的目的是提供一种使用新型有机铝化合物支撑铬催化剂生产的聚乙烯、一种生产聚乙烯的方法和一种含有该聚乙烯的中空塑料模具，该聚乙烯具有优异的成型性和抗冲击性，并在刚性和耐久性之间取得优异的平衡。本发明的聚乙烯是使用铬催化剂聚合而成的，在支化度分布曲线的最大值处，重量平均分子量（Mw）为 30,000 或更高，该曲线显示了具有 4 个或更多碳原子的短链分支的分子量依赖性。
• US9428508B2
  申请人：——

  公开号：US9428508B2

  公开（公告）日：2016-08-30