3-methylsulfinyl-6-[(1-benzyl)-4-pyrazolyl]-1,2,4-triazine | 1380345-49-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-methylsulfinyl-6-[(1-benzyl)-4-pyrazolyl]-1,2,4-triazine
• 英文别名: 6-(1-Benzylpyrazol-4-yl)-3-methylsulfinyl-1,2,4-triazine
• CAS: 1380345-49-2
• 化学式: C₁₄H₁₃N₅OS
• 分子量: 299.356
• InChiKey: NACGGXKOWOPQKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  92.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF
  申请人：Duan Wenhu

  公开号：US20130324542A1

  公开（公告）日：2013-12-05

  The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition including a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.

  本发明涉及结构新颖的[1,2,4]三唑并[4,3-b][1,2,4]三嗪化合物，其化学式为(I)或(II)，其药学上可接受的盐、前药、水合物或溶剂化物，以及化合物的制备方法、包括治疗有效量的化合物的制药组合物，以及其作为蛋白酪氨酸激酶抑制剂，特别是作为c-Met抑制剂，在制备与c-Met异常相关的疾病的药物的预防和/或治疗中的用途。
• [1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUND, PREPARATION METHOD AND USE THEREOF
  申请人：Shanghai Institute Materia Medica, Chinese Academy Of Sciences

  公开号：EP2650293A1

  公开（公告）日：2013-10-16

  The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition comprising a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.

  本发明涉及一种结构新颖的由式(I)或式(II)表示的[1,2,4]三唑并[4,3-b][1,2,4]三嗪化合物、其药学上可接受的盐、其原药、其水合物或溶液，还涉及该化合物的制备方法、一种包含治疗有效量化合物的药物组合物，以及其作为蛋白酪氨酸激酶抑制剂，特别是作为 c-Met 抑制剂在制备预防和/或治疗与 c-Met 异常相关疾病的药物中的用途。