2,5-bis (4-phenylacyl chloride)-1,3,4-oxadiazole | 40874-25-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-bis (4-phenylacyl chloride)-1,3,4-oxadiazole
• 英文别名: 4,4'-(1,3,4-Oxadiazole-2,5-diyl)dibenzoyl chloride；4-[5-(4-carbonochloridoylphenyl)-1,3,4-oxadiazol-2-yl]benzoyl chloride
• CAS: 40874-25-7
• 化学式: C₁₆H₈Cl₂N₂O₃
• 分子量: 347.157
• InChiKey: PEXYKZYRRDLSHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  罗丹明B乙二胺 、 2,5-bis (4-phenylacyl chloride)-1,3,4-oxadiazole 以 乙腈 为溶剂， 反应 6.0h， 以80%的产率得到
  参考文献：
  名称：

  A selective colorimetric and fluorescent sensor for Al3+ ion and its application to cellular imaging

  摘要：

  A new rhodamine-based fluorescent turn-on chemosensor (L) for selective detection of Al3+ ion has been developed and characterized. The fluorescent chemosensor L was synthesized by the reaction of intermediate (4) with 2,5-bis (4-phenylacyl chloride)-1,3,4-oxadiazole (3). The chemosensor L displays an excellent selective and sensitive response to Al3+ ion over other metal ions, in which the spirocyclic (non-fluorescent) to ring opened amide (fluorescent) process was utilized and a 1:2 stoichiometry for L-Al3+ complex was formed with an association constant of 2.03 x 10(3) M-1. Furthermore, chemosensor L can be applied as a fluorescent probe for monitoring Al3+ in living cells by performing cell imaging studies. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2015.01.015
• 作为产物：
  描述：

  4-[5-(4-羧基苯基)-1,3,4-恶二唑-2-基]苯甲酸 在 氯化亚砜 作用下， 以 苯 为溶剂， 生成 2,5-bis (4-phenylacyl chloride)-1,3,4-oxadiazole
  参考文献：
  名称：

  A selective colorimetric and fluorescent sensor for Al3+ ion and its application to cellular imaging

  摘要：

  A new rhodamine-based fluorescent turn-on chemosensor (L) for selective detection of Al3+ ion has been developed and characterized. The fluorescent chemosensor L was synthesized by the reaction of intermediate (4) with 2,5-bis (4-phenylacyl chloride)-1,3,4-oxadiazole (3). The chemosensor L displays an excellent selective and sensitive response to Al3+ ion over other metal ions, in which the spirocyclic (non-fluorescent) to ring opened amide (fluorescent) process was utilized and a 1:2 stoichiometry for L-Al3+ complex was formed with an association constant of 2.03 x 10(3) M-1. Furthermore, chemosensor L can be applied as a fluorescent probe for monitoring Al3+ in living cells by performing cell imaging studies. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2015.01.015

文献信息

• JAVAID, KHALID;SMITH, D. M., J. CHEM. RES. MICROFICHE, 1984, N 4, 118-119
  作者：JAVAID, KHALID、SMITH, D. M.

  DOI：——

  日期：——