N-(pyrimidin-5-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine | 1330625-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: N-(pyrimidin-5-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
• 英文别名: N-pyrimidin-5-yl-1H-pyrazolo[4,3-b]pyridin-3-amine
• CAS: 1330625-07-4
• 化学式: C₁₀H₈N₆
• 分子量: 212.214
• InChiKey: WJHYYQMBJGCZPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] PYRAZOLOPYRIDINE, PYRAZOLOPYRAZINE, PYRAZOLOPYRIMIDINE, PYRAZOLOTHIOPHENE AND PYRAZOLOTHIAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOUNDS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION<br/>[FR] COMPOSÉS DE PYRAZOLOPYRIDINE, DE PYRAZOLOPYRAZINE, DE PYRAZOLOPYRIMIDINE, DE PYRAZOLOTHIOPHÈNE ET DE PYRAZOLOTHIAZOLE EN TANT QUE POTENTIALISATEURS ALLOSTÉRIQUES DU SOUS-TYPE 4 DU RÉCEPTEUR DU GLUTAMATE MÉTABOTROPIQUE (MGLUR4), COMPOSÉS ET PROCÉDÉS D
  申请人：UNIV VANDERBILT

  公开号：WO2011100607A1

  公开（公告）日：2011-08-18

  Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

  吡唑吡啶，吡唑吡嗪，吡唑嘧啶，吡唑噻吩和吡唑噻唑化合物可用作代谢型谷氨酸受体亚型4（mGluR4）的别构势化剂/正别构调节剂；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物的方法，例如用于治疗神经系统和精神疾病或其他与谷氨酸功能紊乱有关的疾病状态。
• Pyrazolopyridine, Pyrazolopyrazine, Pyrazolopyrimidine, Pyrazolothiophene and Pyrazolothiazole Compounds as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction
  申请人：Conn P. Jeffrey

  公开号：US20130096110A1

  公开（公告）日：2013-04-18

  Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

  这段文字描述了Pyrazolopyridine、pyrazolopyrazine、pyrazolopyrimidine、pyrazolothiophene和pyrazolothiazole化合物，它们可作为代谢型谷氨酸受体亚型4(mGluR4)的变构增强剂/正变构调节剂。同时还介绍了这些化合物的合成方法、包含这些化合物的药物组合物以及使用这些化合物治疗神经和精神障碍或其他与谷氨酸功能失调有关的疾病的方法。
• US9163015B2
  申请人：——

  公开号：US9163015B2

  公开（公告）日：2015-10-20