[(3R)-4,4-dimethyl-2-oxooxolan-3-yl] (2R)-5-(1,3-dioxoisoindol-2-yl)-2-phenylpentanoate | 284465-62-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(3R)-4,4-dimethyl-2-oxooxolan-3-yl] (2R)-5-(1,3-dioxoisoindol-2-yl)-2-phenylpentanoate
• CAS: 284465-62-9
• 化学式: C₂₅H₂₅NO₆
• 分子量: 435.477
• InChiKey: PKTIUTOFHGZCRI-XLIONFOSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  90
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [(3R)-4,4-dimethyl-2-oxooxolan-3-yl] (2R)-5-(1,3-dioxoisoindol-2-yl)-2-phenylpentanoate 生成 (R)-(-)-α-phenyl δ-amino valeric acid
  参考文献：
  名称：

  First asymmetric synthesis of (R)-(−)-α-phenyl δ-amino valeric acid

  摘要：

  An efficient synthesis of the (R)-(-)-alpha-phenyl delta-amino valeric acid 1 is described starting from commercially available compounds. The key intermediate in this synthesis is the corresponding totally protected prochiral ketene. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00077-x
• 作为产物：
  描述：

  苯乙酸苄酯 在 N,N-二甲基丙烯基脲 、 草酰氯 、 三乙胺 、 lithium diisopropyl amide 作用下， 反应 1.0h， 生成 [(3R)-4,4-dimethyl-2-oxooxolan-3-yl] (2R)-5-(1,3-dioxoisoindol-2-yl)-2-phenylpentanoate
  参考文献：
  名称：

  First asymmetric synthesis of (R)-(−)-α-phenyl δ-amino valeric acid

  摘要：

  An efficient synthesis of the (R)-(-)-alpha-phenyl delta-amino valeric acid 1 is described starting from commercially available compounds. The key intermediate in this synthesis is the corresponding totally protected prochiral ketene. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00077-x

文献信息

• First asymmetric synthesis of (R)-(−)-α-phenyl δ-amino valeric acid
  作者：Monique Calmes、Françoise Escale、Emmanuelle Juan、Marc Rolland、Jean Martinez

  DOI：10.1016/s0957-4166(00)00077-x

  日期：2000.4

  An efficient synthesis of the (R)-(-)-alpha-phenyl delta-amino valeric acid 1 is described starting from commercially available compounds. The key intermediate in this synthesis is the corresponding totally protected prochiral ketene. (C) 2000 Elsevier Science Ltd. All rights reserved.