N-phthalyl α-phenyl δ-amino valeric acid | 98739-17-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phthalyl α-phenyl δ-amino valeric acid
• 英文别名: (+/-)-2-Phenyl-5-phthalimido-valeriansaeure；5-Phthalimido-2-phenyl-pentansaeure；2-phenyl-5-phthalimido-pentanoic acid；5-(1,3-Dioxoisoindol-2-yl)-2-phenylpentanoic acid
• CAS: 98739-17-4
• 化学式: C₁₉H₁₇NO₄
• 分子量: 323.348
• InChiKey: WJUCGSTUHLVAQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-phthalyl α-phenyl δ-amino valeric acid 在 草酰氯 作用下， 生成 5-(1,3-Dioxoisoindol-2-yl)-2-phenylpentanoyl chloride
  参考文献：
  名称：

  First asymmetric synthesis of (R)-(−)-α-phenyl δ-amino valeric acid

  摘要：

  An efficient synthesis of the (R)-(-)-alpha-phenyl delta-amino valeric acid 1 is described starting from commercially available compounds. The key intermediate in this synthesis is the corresponding totally protected prochiral ketene. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00077-x
• 作为产物：
  描述：

  苯乙酸苄酯 在 N,N-二甲基丙烯基脲 、 lithium diisopropyl amide 作用下， 生成 N-phthalyl α-phenyl δ-amino valeric acid
  参考文献：
  名称：

  First asymmetric synthesis of (R)-(−)-α-phenyl δ-amino valeric acid

  摘要：

  An efficient synthesis of the (R)-(-)-alpha-phenyl delta-amino valeric acid 1 is described starting from commercially available compounds. The key intermediate in this synthesis is the corresponding totally protected prochiral ketene. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00077-x

文献信息

• First asymmetric synthesis of (R)-(−)-α-phenyl δ-amino valeric acid
  作者：Monique Calmes、Françoise Escale、Emmanuelle Juan、Marc Rolland、Jean Martinez

  DOI：10.1016/s0957-4166(00)00077-x

  日期：2000.4

  An efficient synthesis of the (R)-(-)-alpha-phenyl delta-amino valeric acid 1 is described starting from commercially available compounds. The key intermediate in this synthesis is the corresponding totally protected prochiral ketene. (C) 2000 Elsevier Science Ltd. All rights reserved.