(R)-α-azido-3,3-dimethyl butanoic acid | 131833-99-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-α-azido-3,3-dimethyl butanoic acid
• 英文别名: (2R)-2-Azido-3,3-dimethylbutanoic acid；(2R)-2-azido-3,3-dimethylbutanoic acid
• CAS: 131833-99-3
• 化学式: C₆H₁₁N₃O₂
• 分子量: 157.172
• InChiKey: VAIDLLPVBKRXOK-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  51.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-bromo-3,3-dimethylbutanoyl chloride 、 D-(-)-泛酰内酯 生成 (S)-2-azido-3,3-dimethylbutanoic acid 、 (R)-α-azido-3,3-dimethyl butanoic acid
  参考文献：
  名称：

  Asymmetric synthesis of alpha-halo esters

  摘要：

  The reaction of (R)-Pantolactone with alpha-halogenated ketenes has been found to proceed with good to excellent diastereoselectivities (de 75 to > 95%). The (R)-Pantolacto chiral auxiliary induced the (S)-configuration at the new chiral center in most cases.

  DOI：

  10.1016/s0040-4039(00)61779-3

文献信息

• Asymmetric synthesis of alpha-halo esters
  作者：Tony Durst、Kevin Koh

  DOI：10.1016/s0040-4039(00)61779-3

  日期：1992.11

  The reaction of (R)-Pantolactone with alpha-halogenated ketenes has been found to proceed with good to excellent diastereoselectivities (de 75 to > 95%). The (R)-Pantolacto chiral auxiliary induced the (S)-configuration at the new chiral center in most cases.