3-methyl-indan-4-ylamine | 1245938-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 3-methyl-indan-4-ylamine
• 英文别名: 3-methyl-2,3-dihydro-1H-inden-4-amine
• CAS: 1245938-33-3
• 化学式: C₁₀H₁₃N
• mdl: MFCD19215854
• 分子量: 147.22
• InChiKey: VNCPXXRZQSNQIK-UHFFFAOYSA-N

物化性质

• 沸点：
  242.5±29.0 °C(Predicted)
• 密度：
  1.045±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-methyl-indan-4-ylamine 、 benzofuran-7-carboxylic acid chloride 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 benzofuran-7-carboxylic acid (3-methyl-indan-4-yl)-amide
  参考文献：
  名称：

  Minimalist End Groups for Control of Absolute Helicity in Salen- and Salophen-Based Metallofoldamers

  摘要：

  (S)-1-Methylindan end groups are effective controllers of absolute helicity in Ni-salen- and Ni-salophen-based foldamers derived from (R,R)-trans-1,2-cyclohexanediamine and 1,2-phenylenediamine, respectively. Evidence for the helicity of the described complexes was provided through X-ray crystallography and study of chiroptical properties in solution. The chiral end groups control the absolute sense of helicity for the salen complexes, even in a case where the helical bias of the end group is mismatched relative to that of the internal diamine.

  DOI：

  10.1021/ol101583v
• 作为产物：
  描述：

  N-(3-methyl-indan-4-yl)acetamide 在 盐酸 、 水 作用下， 反应 3.0h， 以91%的产率得到3-methyl-indan-4-ylamine
  参考文献：
  名称：

  Minimalist End Groups for Control of Absolute Helicity in Salen- and Salophen-Based Metallofoldamers

  摘要：

  (S)-1-Methylindan end groups are effective controllers of absolute helicity in Ni-salen- and Ni-salophen-based foldamers derived from (R,R)-trans-1,2-cyclohexanediamine and 1,2-phenylenediamine, respectively. Evidence for the helicity of the described complexes was provided through X-ray crystallography and study of chiroptical properties in solution. The chiral end groups control the absolute sense of helicity for the salen complexes, even in a case where the helical bias of the end group is mismatched relative to that of the internal diamine.

  DOI：

  10.1021/ol101583v

文献信息

• Minimalist End Groups for Control of Absolute Helicity in Salen- and Salophen-Based Metallofoldamers
  作者：Zhenzhen Dong、James N. Plampin、Glenn P. A. Yap、Joseph M. Fox

  DOI：10.1021/ol101583v

  日期：2010.9.17

  (S)-1-Methylindan end groups are effective controllers of absolute helicity in Ni-salen- and Ni-salophen-based foldamers derived from (R,R)-trans-1,2-cyclohexanediamine and 1,2-phenylenediamine, respectively. Evidence for the helicity of the described complexes was provided through X-ray crystallography and study of chiroptical properties in solution. The chiral end groups control the absolute sense of helicity for the salen complexes, even in a case where the helical bias of the end group is mismatched relative to that of the internal diamine.