1-(3-Nitrophenyl)-1-butanone hydrazone | 280760-10-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Nitrophenyl)-1-butanone hydrazone
• 英文别名: 1-(3-nitrophenyl)butylidenehydrazine
• CAS: 280760-10-3
• 化学式: C₁₀H₁₃N₃O₂
• 分子量: 207.232
• InChiKey: QRENLZZMRRLMOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(3-Nitrophenyl)-1-butanone hydrazone 在 manganese(IV) oxide 、 lithium aluminium tetrahydride 、 水 、 铁粉 、 calcium chloride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 为溶剂， 生成
  参考文献：
  名称：

  SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands

  摘要：

  3-Azabicyclo[3.1.0] hexane compounds were designed as novel achiral mu opioid receptor ligands for the treatment of pruritus in dogs. In this paper, we describe the SAR of this class of opioid ligand, highlighting changes to the lead structure which led to compounds having picomolar binding affinity, selective for the mu receptor over delta and kappa subtypes. Some subtleties of functional activity will also be described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.099
• 作为产物：
  描述：

  3-硝基苯丁酮 在 肼 作用下， 以 乙醇 、 水 为溶剂， 生成 1-(3-Nitrophenyl)-1-butanone hydrazone
  参考文献：
  名称：

  SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands

  摘要：

  3-Azabicyclo[3.1.0] hexane compounds were designed as novel achiral mu opioid receptor ligands for the treatment of pruritus in dogs. In this paper, we describe the SAR of this class of opioid ligand, highlighting changes to the lead structure which led to compounds having picomolar binding affinity, selective for the mu receptor over delta and kappa subtypes. Some subtleties of functional activity will also be described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.099

文献信息

• 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
  申请人：Pfizer, Inc.

  公开号：US20030013875A1

  公开（公告）日：2003-01-16

  Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances. 1

  公式（I）的化合物、其盐和前药被揭示为鸦片类结合剂，可用于治疗鸦片类介导的疾病，其中取代基的定义如本文所述。还描述了制造这些物质的过程。
• 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy
  申请人：Pfizer INC

  公开号：US06313312B1

  公开（公告）日：2001-11-06

  Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances.

  本文披露了化学式(I)的化合物、它们的盐和前药，其中置换基的定义如本文所述，这些化合物作为鸦片类药物结合剂在治疗鸦片类介导的疾病方面有用。还描述了制备这些物质的过程。