2-(3,3-dimethylmorpholino)ethanamine 、 6-methyl-5-(7-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridine-3-carboxamido)nicotinic acid 在
N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下,
以
N,N-二甲基甲酰胺 为溶剂,
以16%的产率得到N-(5-((2-(3,3-dimethylmorpholino)ethyl)carbamoyl)-2-methylpyridin-3-yl)-7-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridine-3-carboxamide