5-(4-(benzyloxy)phenyl)-3-(4-bromophenyl)-4,5-dihydroisoxazole | 1198426-65-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(4-(benzyloxy)phenyl)-3-(4-bromophenyl)-4,5-dihydroisoxazole
• 英文别名: 5-(4-(Benzyloxy)phenyl)-3-(4-bromophenyl)-4,5-dihydroisoxazole；3-(4-bromophenyl)-5-(4-phenylmethoxyphenyl)-4,5-dihydro-1,2-oxazole
• CAS: 1198426-65-1
• 化学式: C₂₂H₁₈BrNO₂
• 分子量: 408.294
• InChiKey: LHTJEPDGCHPGPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  30.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(4-(benzyloxy)phenyl)-1-(4-bromophenyl)prop-2-en-1-one 在 盐酸羟胺 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以63%的产率得到5-(4-(benzyloxy)phenyl)-3-(4-bromophenyl)-4,5-dihydroisoxazole
  参考文献：
  名称：

  Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives

  摘要：

  A new series of N-phenylpyrazoles and dihydroisoxazles was synthesized starting from alpha,beta-unsaturated ketones in basic media using phenyl hydrazine and hydroxylamine HCl, respectively. Antiviral evaluation of the target compounds revealed that the dihydroisoxazole derivatives have promising antiviral activity against hepatitis A virus and herpes simplex virus type 1.

  DOI：

  10.1007/s00044-009-9248-y

文献信息

• Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives
  作者：Adel A. Rashad、Osama I. El-Sabbagh、Mohamed M. Baraka、Samy M. Ibrahim、Christophe Pannecouque、Graciela Andrei、Robert Snoeck、Jan Balzarini、Ahmed Mostafa

  DOI：10.1007/s00044-009-9248-y

  日期：2010.12

  A new series of N-phenylpyrazoles and dihydroisoxazles was synthesized starting from alpha,beta-unsaturated ketones in basic media using phenyl hydrazine and hydroxylamine HCl, respectively. Antiviral evaluation of the target compounds revealed that the dihydroisoxazole derivatives have promising antiviral activity against hepatitis A virus and herpes simplex virus type 1.