5t-(4-methoxy-phenyl)-penta-2t,4-dienoyl chloride | 443360-66-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5t-(4-methoxy-phenyl)-penta-2t,4-dienoyl chloride
• 英文别名: 5t-(4-methoxy-phenyl)-penta-2t,4-dienoyl chloride；5t-(4-Methoxy-phenyl)-penta-2t,4-dienoylchlorid
• CAS: 443360-66-5
• 化学式: C₁₂H₁₁ClO₂
• 分子量: 222.671
• InChiKey: AQEHNVKWQQJGIB-ZUVMSYQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.03
• 重原子数：
  15.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  5t-(4-methoxy-phenyl)-penta-2t,4-dienoyl chloride 在 palladium on activated charcoal 氢气 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 0.5h， 生成 5-(4-methoxyphenyl)pentanoic acid N-methylpiperazine amide
  参考文献：
  名称：

  Structure–activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities

  摘要：

  Inhibitors of drug metabolism have important implications in pharmaco-toxicology and agriculture. We have reported earlier that piperine, a major alkaloid of black and long peppers inhibits both constitutive and inducible cytochrome P450 (CYP)dependent drug metabolising enzymes. In the present study, an attempt has been made to prepare several novel synthetic analogues so as to relate various modifications in the parent molecule to the inhibition of CYP activities. Two types of mono-oxygenase reactions arylhydrocarbon hydroxylase (AHH) and 7-methoxycoumarin-O-demethylase (MOCD) have been studied. Inhibition studies were investigated in rat microsomal fraction prepared from untreated, 3MC- and PB- treated rat liver in vitro. Modifications were introduced into the piperine molecule: (i) in the phenyl nucleus, (ii) in the side chain and (iii) in the basic moiety. Thus, 38 compounds have been subjected to such studies, and simultaneously an attempt has also been made to arrive at the structure-activity relationship of synthetic analogues. In general, most of the inhibitory potential of the parent molecule is lost with modification in either of the three components of piperine. Saturation of the side chain resulted in significantly enhanced inhibition of CYP while modifications in the phenyl and basic moieties in few analogues offered maximal selectivity in inhibiting either constitutive or inducible CYP activities. Thus Few novel analogues as CYP inactivators have been synthesized which may have important consequences in pharmacokinetics and bioavailability of drugs. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00273-4
• 作为产物：
  描述：

  methyl 5-(4-methoxyphenyl)-2,4-pentadienoate 在 草酰氯 作用下， 以 苯 为溶剂， 生成 5t-(4-methoxy-phenyl)-penta-2t,4-dienoyl chloride
  参考文献：
  名称：

  Banerji, Avijit; Ghosal, Tapasree; Acharyya, Aditi K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 6, p. 546 - 549

  摘要：

  DOI：

文献信息

• Banerji, Avijit; Banerjee, Tapasri; Sengupta, Ratna, Journal of the Indian Chemical Society, 2002, vol. 79, # 11, p. 876 - 883
  作者：Banerji, Avijit、Banerjee, Tapasri、Sengupta, Ratna、Sengupta, Piyali、Das, Chittaranjan、Sahu, Anita

  DOI：——

  日期：——
• Vorlaender; Gieseler, Journal fur praktische Chemie (Leipzig 1954), 1929, vol. <2>121, p. 239
  作者：Vorlaender、Gieseler

  DOI：——

  日期：——