Methanesulfonic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl ester | 220801-88-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: Methanesulfonic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl ester
• CAS: 220801-88-7
• 化学式: C₁₁H₂₆O₄SSi
• 分子量: 282.477
• InChiKey: CALFBUVPHQJFTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.62
• 重原子数：
  17.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  Methanesulfonic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl ester 在 二异丁基氢化铝 、 三苯基膦 、 锌 作用下， 生成 tert-Butyl-(5,5-dibromo-2-methyl-pent-4-enyloxy)-dimethyl-silane
  参考文献：
  名称：

  Relative Asymmetric Induction in the Intramolecular Reaction between Alkynes and Cyclopropylcarbene−Chromium Complexes:  Stereocontrolled Synthesis of Five-Membered Rings Fused to Oxygen Heterocycles

  摘要：

  Synthesis of cyclopentenone derivatives fused to oxygen heterocycles by means of the intramolecular coupling of alkynes and cyclopropylcarbene-chromium complexes has been examined for a variety of cases in which the tethering chain features a stereogenic center. In some cases, this process proceeds with a very high degree of stereoselectivity; however, the extent and direction of relative asymmetric induction is very dependent upon the position of the chiral atom within the tethering chain and the length of the tethering chain. In the best case, featuring a two-carbon tether and a stereogenic center at the homopropargylic position (complex 1N), the heterocyclic ring was produced with 97:3 selectivity for the cis heterocycle (3N). In the worst case, featuring a three-carbon tether and a stereogenic center at the homopropargylic position (complexes 1F and ii), no stereoselectivity was observed. Improvement in stereoselectivity was noticed when terminal alkynes were replaced by silylated alkynes and when proton sources were eliminated from the reaction.

  DOI：

  10.1021/jo982144q
• 作为产物：
  描述：

  methyl 2-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)propanoate 在 二异丁基氢化铝 、 三乙胺 作用下， 生成 Methanesulfonic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl ester
  参考文献：
  名称：

  Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARδ agonists

  摘要：

  A novel series of potent and selective PPAR delta agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.007