7-benzyloxy-1-(4-benzyloxy-benzyl)-6-methoxy-3,4-dihydro-isoquinoline; hydrochloride | 132257-18-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 7-benzyloxy-1-(4-benzyloxy-benzyl)-6-methoxy-3,4-dihydro-isoquinoline; hydrochloride
• 英文别名: 7-Benzyloxy-1-(4-benzyloxy-benzyl)-6-methoxy-3,4-dihydro-isochinolin; Hydrochlorid；6-Methoxy-7-phenylmethoxy-1-[(4-phenylmethoxyphenyl)methyl]-3,4-dihydroisoquinoline;hydrochloride
• CAS: 132257-18-2
• 化学式: C₃₁H₂₉NO₃*ClH
• 分子量: 500.037
• InChiKey: NXKNNDALAGQTKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.86
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  40
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-benzyloxy-1-(4-benzyloxy-benzyl)-6-methoxy-3,4-dihydro-isoquinoline; hydrochloride 在 乙醇 、 sodium ethanolate 、 镍 、 二乙胺 作用下， 160.0 ℃ 、5.88 MPa 条件下， 生成 N-methylcoclaurine
  参考文献：
  名称：

  钠在液氨上phaeanthine的动作，OO '-dimethylcurine，和OO ' -二甲基异chondrodendrine

  摘要：

  DOI：

  10.1039/jr9540000669

文献信息

• Identification and characterization of human neuronal voltage-gated calcium channel gamma 3 subunit gene
  作者：Jiahui Xia、Huali Zhang、Dongsheng Tang、Xixiang Tang、Heping Dai、Qian Pan、Zhigao Long、Xiaodong Liao

  DOI：10.1007/bf02886324

  日期：2000.12

  By homologous expressed sequence tag (EST) searching, one EST (GenBank: W29095) was obtained, which shows 75% identity in 435 bp overlap with the coding sequence of mouse Cacng2 gene. A 1 545 bp cDNA fragment was obtained from the nested polymerase chain reaction (PCR) and rapid applification of cDNA end (RACE) reaction in the human brain prefrontal cortex cDNA library and the human brain Ready cDNA with the primers designed on W29095. The fragment contained a 948-bp open reading frame (ORF) encoding 315 amino acids, and was named CACNG3. As it was identical to a BAC clone (GenBank: AC004125) from chromosome 16p12-p13.1, the CACNG3 gene was mapped to human chromosome 16p12-p13.1, and the coding region was composed of 4 exons. Reverse transcription PCR (RT-PCR) analysis showed that the CACNG3 gene expressed in human adult brain and fetal brain. Single strand comformation polymorphism (SSCP) analysis was performed in 3 pedigrees with autosomal recessive retinitis pigmentosa, 8 pedigrees with autosomal recessive retinitis pigmentosa accompanied by deafness and 2 pedigrees with epilepsy, but no mutation was detected.
• Yamaguchi; Nakano, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 1106
  作者：Yamaguchi、Nakano

  DOI：——

  日期：——
• The action of sodium in liquid ammonia on phaeanthine, OO′-dimethylcurine, and OO′-dimethylisochondrodendrine
  作者：D. A. A. Kidd、James Walker

  DOI：10.1039/jr9540000669

  日期：——