1-phenyl-2-(2-bromophenyl)-1-(2-(7-bromo-3-methoxy)naphthyl)-4-(N,N-dimethylamino)-butan-2-ol | 1346998-71-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-phenyl-2-(2-bromophenyl)-1-(2-(7-bromo-3-methoxy)naphthyl)-4-(N,N-dimethylamino)-butan-2-ol
• 英文别名: 1-(7-Bromo-3-methoxynaphthalen-2-yl)-2-(2-bromophenyl)-4-(dimethylamino)-1-phenylbutan-2-ol
• CAS: 1346998-71-7
• 化学式: C₂₉H₂₉Br₂NO₂
• 分子量: 583.363
• InChiKey: QPMAMPCRTCIKDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• AROMATIC BUTAN-2-OL COMPOUNDS AND PREPARATION AND USES THEREOF
  申请人：Li Song

  公开号：US20130085183A1

  公开（公告）日：2013-04-04

  Aromatic butan-2-ol compounds, preparation methods for making the compounds, and uses of the compounds are provided. Specifically, the compound of Formula I, or an optical isomer, racemate, diastereomer, pharmaceutically acceptable salt, or solvate thereof, is provided, where each of the substituents is defined. In addition, a pharmaceutical composition containing the compound, and the use of the compound in manufacture of a medicament for the treatment and/or prophylaxis of a disease or disorder caused by tubercle bacillus infection, is provided.

  提供芳香族丁二醇化合物、制备该化合物的方法以及该化合物的用途。具体地，提供式I的化合物或其光学异构体、外消旋体、对映异构体、药学上可接受的盐或溶剂化物，其中每个取代基都有定义。此外，提供含有该化合物的药物组合物，并提供将该化合物用于制造治疗和/或预防由结核分枝杆菌感染引起的疾病或疾病的药物的用途。
• US8674136B2
  申请人：——

  公开号：US8674136B2

  公开（公告）日：2014-03-18
• [EN] AROMATIC BUTAN-2-OL COMPOUNDS, PREPARATION METHODS AND USES THEREOF<br/>[FR] COMPOSÉS AROMATIQUES DE BUTAN-2-OL, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS UTILISATIONS
  申请人：INST PHARM & TOXICOLOGY AMMS

  公开号：WO2011143932A1

  公开（公告）日：2011-11-24

  Provided are compounds shown by formula I, optical isomers, racemes, diastereoisomers, pharmaceutically acceptable salts or solvates thereof, wherein each substituent has the meaning as defined in the specification. Also provided are their preparation methods, pharmaceutical compositions containing them and uses of said compounds for preparation of drugs useful for the treatment and/or prophylaxis of diseases or disorders caused by the infection of mycobacterium tuberculosis.