2,8-Dimethyl-1,10-trimethylenpiperazino<1,2-a>indol | 27853-12-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,8-Dimethyl-1,10-trimethylenpiperazino<1,2-a>indol
• 英文别名: 3,8-dimethyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole；3,8-Dimethyl-2,3,3a,4,5,6-hexahydro-1h-pyrazino[3,2,1-jk]carbazole；4,12-dimethyl-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10(15),11,13-tetraene
• CAS: 27853-12-9
• 化学式: C₁₆H₂₀N₂
• 分子量: 240.348
• InChiKey: XXEYXLGPFYMZNX-UHFFFAOYSA-N

物化性质

• 沸点：
  402.8±33.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  8.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• TRIAZOLE DERIVATIVES FOR TREATING ALZHEIMER'S DISEASE AND RELATED CONDITIONS
  申请人：Fischer Christian

  公开号：US20100222320A1

  公开（公告）日：2010-09-02

  Compounds of formula I: Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain, in particular Alzheimer's disease.

  公式为I的化合物：选择性地减弱Aβ（1-42）的产生，因此可用于治疗或预防与Aβ在大脑中沉积相关的疾病，特别是阿尔茨海默病。
• TETRAHYDROCARBAZOLES AS ACTIVE AGENTS FOR INHIBITING VEGF PRODUCTION BY TRANSLATIONAL CONTROL
  申请人：PTC Therapeutics, Inc.

  公开号：US20150141418A1

  公开（公告）日：2015-05-21

  The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.

  本发明涉及用于抑制血管生成的方法、化合物和组合物。更具体地，本发明涉及用于抑制VEGF产生的方法、化合物和组合物。
• METHODS FOR TREATING MULTIPLE SCLEROSIS USING TETRACYCLIC PYRAZINOINDOLES
  申请人：Deftereos Spyros

  公开号：US20110268699A1

  公开（公告）日：2011-11-03

  Methods and pharmaceutical compositions for treating multiple sclerosis are described. The methods and pharmaceutical compositions include a therapeutically effective amount of one or more tetracyclic pyrazinoindoles, and/or pharmaceutically acceptable salts thereof.
• COMPOSITIONS AND METHODS FOR TREATING MITOCHONDRIAL DISEASES
  申请人：BIOVISTA, INC.

  公开号：US20160213667A1

  公开（公告）日：2016-07-28

  The invention described herein relates to methods for treating mitochondrial diseases. In particular, the invention relates to methods for treating mitochondrial diseases by administering therapeutically effective amounts of one or more tetracyclic pyrazinoindoles, and/or pharmaceutically acceptable salts thereof.
• US8242150B2
  申请人：——

  公开号：US8242150B2

  公开（公告）日：2012-08-14